Literature DB >> 10673101

The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.

M Maitrejean1, G Comte, D Barron, K El Kirat, G Conseil, A Di Pietro.   

Abstract

A new series of potential flavonoidic modulators of P-glycoprotein activity has been prepared. The flavanolignan silybin was first oxidised to dehydrosilybin and then C-alkylated with either prenyl or geranyl bromide. The resulting isoprenoid dehydrosilybins were shown to display high in vitro affinities for direct binding to P-glycoprotein, which ranged them among the best flavonoids ever tested.

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Year:  2000        PMID： 10673101     DOI： 10.1016/s0960-894x(99)00636-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

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2.  Population pharmacokinetics of sirolimus in de novo Chinese adult renal transplant patients.

Authors:  Zheng Jiao; Xiao-jin Shi; Zhong-dong Li; Ming-kang Zhong
Journal:  Br J Clin Pharmacol       Date:  2009-07       Impact factor: 4.335

3.  High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.

Authors:  J M Pérez-Victoria; F J Pérez-Victoria; G Conseil; M Maitrejean; G Comte; D Barron; A Di Pietro; S Castanys; F Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

4.  Molecular characterization of a membrane-bound prenyltransferase specific for isoflavone from Sophora flavescens.

Authors:  Kanako Sasaki; Yusuke Tsurumaru; Hirobumi Yamamoto; Kazufumi Yazaki
Journal:  J Biol Chem       Date:  2011-05-16       Impact factor: 5.157

5.  Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans.

Authors:  Bill J Gurley; Gary W Barone; D Keith Williams; Julie Carrier; Philip Breen; C Ryan Yates; Peng-fei Song; Martha A Hubbard; Yudong Tong; Sreekhar Cheboyina
Journal:  Drug Metab Dispos       Date:  2005-10-12       Impact factor: 3.922

Review 6.  Herb-drug interactions: a literature review.

Authors:  Zeping Hu; Xiaoxia Yang; Paul Chi Lui Ho; Sui Yung Chan; Paul Wan Sia Heng; Eli Chan; Wei Duan; Hwee Ling Koh; Shufeng Zhou
Journal:  Drugs       Date:  2005       Impact factor: 9.546

7.  Cloning and characterization of naringenin 8-prenyltransferase, a flavonoid-specific prenyltransferase of Sophora flavescens.

Authors:  Kanako Sasaki; Kouji Mito; Kazuaki Ohara; Hirobumi Yamamoto; Kazufumi Yazaki
Journal:  Plant Physiol       Date:  2008-01-24       Impact factor: 8.340

Review 8.  Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management.

Authors:  Sumit Jain; Vijay Rathod; Rameshwar Prajapati; Prajwal P Nandekar; Abhay T Sangamwar
Journal:  Mol Divers       Date:  2014-09-12       Impact factor: 2.943

9.  3-O-Alkyl-2,3-dehydrosilibinins: Two synthetic approaches and in vitro effects toward prostate cancer cells.

Authors:  Sheng Zhang; Bao Vue; Michael Huang; Xiaojie Zhang; Timmy Lee; Guanglin Chen; Qiang Zhang; Shilong Zheng; Guangdi Wang; Qiao-Hong Chen
Journal:  Bioorg Med Chem Lett       Date:  2016-05-24       Impact factor: 2.823

10.  Regiospecificities and prenylation mode specificities of the fungal indole diterpene prenyltransferases AtmD and PaxD.

Authors:  Chengwei Liu; Atsushi Minami; Motoyoshi Noike; Hiroaki Toshima; Hideaki Oikawa; Tohru Dairi
Journal:  Appl Environ Microbiol       Date:  2013-09-13       Impact factor: 4.792
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