Literature DB >> 10673091

Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems. Part 1: J-111,347 and related compounds.

H Imamura1, N Ohtake, A Shimizu, H Jona, H Sato, R Nagano, R Ushijima, K Yamada, T Hashizume, H Morishima.   

Abstract

1Beta-methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio-side chains at C-2 were designed and synthesized. Evaluation of their antibacterial activities indicated that J-111,347 (1a) is the first example of an extremely broad spectrum antibiotic showing activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa.

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Year:  2000        PMID： 10673091     DOI： 10.1016/s0960-894x(99)00657-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  1 in total

1.  In vitro inhibitory and cytotoxic activity of MFM 501, a novel codonopsinine derivative, against Methicillin-Resistant Staphylococcus aureus clinical isolates.

Authors:  Saiful Azmi Johari; Mastura Mohtar; Sharifah Aminah Syed Mohammad; Rohana Sahdan; Zurina Shaameri; Ahmad Sazali Hamzah; Mohd Fazli Mohammat
Journal:  Biomed Res Int       Date:  2015-02-01       Impact factor: 3.411
  1 in total

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