Literature DB >> 10673046

Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.

C Torres1, L Barreiro, B Dallagiovanna, F Gamarro, S Castanys.   

Abstract

We have characterized the tcpgp1-like gene of Trypanosoma cruzi, a new ATP-binding cassette (ABC) transporter. tcpgp1 codes for a 1035 amino acid protein with a considerable homology to LtpgpA of Leishmania. Tcpgp1 lacks the conserved sequences corresponding to the second nucleotide-binding domain of other ABC transporters due to the insertion of the L1Tc non-LTR retrotransposon.

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Year:  1999        PMID： 10673046     DOI： 10.1016/s0167-4781(99)00195-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

1.  Detection of P-glycoprotein-mediated multidrug resistance against anthelmintics in Haemonchus contortus using anti-human mdr1 monoclonal antibodies.

Authors:  D Kerboeuf; F Guégnard; Y Le Vern
Journal:  Parasitol Res       Date:  2003-07-29       Impact factor: 2.289

2.  A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole.

Authors:  Bianca Zingales; Rafael Gomes Aquino Araujo; Margoth Moreno; Jaques Franco; Pedro Henrique Nascimento Aguiar; Solange Lessa Nunes; Marcelo Nunes Silva; Susan Ienne; Carlos Renato Machado; Adeilton Brandão
Journal:  Mem Inst Oswaldo Cruz       Date:  2015-04-28       Impact factor: 2.743

3.  Metabolic signatures of triatomine vectors of Trypanosoma cruzi unveiled by metabolomics.

Authors:  Luis Caetano M Antunes; Jun Han; Jingxi Pan; Carlos J C Moreira; Patrícia Azambuja; Christoph H Borchers; Nicolas Carels
Journal:  PLoS One       Date:  2013-10-30       Impact factor: 3.240

4.  P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance.

Authors:  Mônica Caroline Oliveira Campos; Denise Barçante Castro-Pinto; Grazielle Alves Ribeiro; Márcia Moreira Berredo-Pinho; Leonardo Henrique Ferreira Gomes; Myrtes Santos da Silva Bellieny; Carla Marins Goulart; Aurea Echevarria; Leonor Laura Leon
Journal:  Parasitol Res       Date:  2013-04-10       Impact factor: 2.289

5.  The L1Tc non-LTR retrotransposon of Trypanosoma cruzi contains an internal RNA-pol II-dependent promoter that strongly activates gene transcription and generates unspliced transcripts.

Authors:  Sara R Heras; Manuel C López; Mónica Olivares; M Carmen Thomas
Journal:  Nucleic Acids Res       Date:  2007-03-16       Impact factor: 16.971
  5 in total

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