OBJECTIVE: The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection. METHOD: Using computer-assisted morphometric techniques, they analyzed the cerebral magnetic resonance images of 34 children with presumed streptococcus-associated OCD and/or tics and 82 healthy comparison children who were matched for age and sex. RESULTS: The average sizes of the caudate, putamen, and globus pallidus, but not of the thalamus or total cerebrum, were significantly greater in the group of children with streptococcus-associated OCD and/or tics than in the healthy children. The differences were similar to those found previously for subjects with Sydenham's chorea compared with normal subjects. CONCLUSIONS: These results support the hypothesis that there is a distinct subgroup of subjects with OCD and/or tics who have enlarged basal ganglia. These findings are consistent with the hypothesis of an autoimmune response to streptococcal infection.
OBJECTIVE: The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection. METHOD: Using computer-assisted morphometric techniques, they analyzed the cerebral magnetic resonance images of 34 children with presumed streptococcus-associated OCD and/or tics and 82 healthy comparison children who were matched for age and sex. RESULTS: The average sizes of the caudate, putamen, and globus pallidus, but not of the thalamus or total cerebrum, were significantly greater in the group of children with streptococcus-associated OCD and/or tics than in the healthy children. The differences were similar to those found previously for subjects with Sydenham's chorea compared with normal subjects. CONCLUSIONS: These results support the hypothesis that there is a distinct subgroup of subjects with OCD and/or tics who have enlarged basal ganglia. These findings are consistent with the hypothesis of an autoimmune response to streptococcal infection.
Authors: Lior Brimberg; Itai Benhar; Adita Mascaro-Blanco; Kathy Alvarez; Dafna Lotan; Christine Winter; Julia Klein; Allon E Moses; Finn E Somnier; James F Leckman; Susan E Swedo; Madeleine W Cunningham; Daphna Joel Journal: Neuropsychopharmacology Date: 2012-04-25 Impact factor: 7.853
Authors: Vilma Gabbay; Barbara J Coffey; Leah E Guttman; Lev Gottlieb; Yisrael Katz; James S Babb; Mia M Hamamoto; Charles J Gonzalez Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2009-05-07 Impact factor: 5.067
Authors: A T Karagulle Kendi; C Krenzel; F W Ott; J R Brace; S K Norberg; S A Kieffer Journal: AJNR Am J Neuroradiol Date: 2008-05-01 Impact factor: 3.825
Authors: Anouk den Braber; Dennis van 't Ent; Danielle C Cath; Judith Wagner; Dorret I Boomsma; Eco J C de Geus Journal: Brain Date: 2010-09-07 Impact factor: 13.501