Literature DB >> 10671293

Flt3 ligand (FL) and its influence on immune reactivity.

M A Antonysamy1, A W Thomson.   

Abstract

Flt3 (fms-like tyrosine kinase 3) ligand (FL) is a potent hematopoietic cytokine that affects the growth and differentiation of progenitor and stem cells both in vivo and in vitro. Its capacity to augment strikingly the numbers of dendritic cells (rare antigen-presenting cells that induce and regulate immune responses) in mice and humans has stimulated considerable interest in its value as an investigational tool and therapeutic agent. In this review, we survey the hematopoietic properties and immunobiology of FL, and examine its therapeutic potential. Copyright 2000 Academic Press.

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Year:  2000        PMID： 10671293     DOI： 10.1006/cyto.1999.0540

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  17 in total

1.  Dendritic cell modification of neutrophil responses to infection after burn injury.

Authors:  Julia Bohannon; Weihua Cui; Edward Sherwood; Tracy Toliver-Kinsky
Journal:  J Immunol       Date:  2010-08-02       Impact factor: 5.422

2.  Reduced herpes simplex virus type 1 latency in Flt-3 ligand-treated mice is associated with enhanced numbers of natural killer and dendritic cells.

Authors:  J R Smith; A M Thackray; R Bujdoso
Journal:  Immunology       Date:  2001-03       Impact factor: 7.397

3.  Small molecule tyrosine kinase inhibitors for the treatment of intestinal inflammation.

Authors:  Maninder Sidhu; Carmen Alonso Cotoner; Bayasi Guleng; Seiji Arihiro; Sunyoung Chang; Kenneth W Duncan; Alfred M Ajami; Mydoanh Chau; Hans-Christian Reinecker
Journal:  Inflamm Bowel Dis       Date:  2011-03-21       Impact factor: 5.325

4.  Efficient production of bioactive recombinant human Flt3 ligand in E. coli.

Authors:  Kenneth Verstraete; Sina Koch; Sevgi Ertugrul; Isabel Vandenberghe; Maarten Aerts; Gonzalez Vandriessche; Christian Thiede; Savvas N Savvides
Journal:  Protein J       Date:  2009-02       Impact factor: 2.371

5.  Attenuation of vaccinia virus by the expression of human Flt3 ligand.

Authors:  Kamila Zurkova; Petr Hainz; Jitka Krystofova; Luda Kutinova; Miloslav Sanda; Sarka Nemeckova
Journal:  Virol J       Date:  2010-05-26       Impact factor: 4.099

6.  Stimulation of hematopoiesis by the Fms-like tyrosine kinase 3 ligand restores bacterial induction of Th1 cytokines in thermally injured mice.

Authors:  Tracy E Toliver-Kinsky; Cheng Y Lin; David N Herndon; Edward R Sherwood
Journal:  Infect Immun       Date:  2003-06       Impact factor: 3.441

7.  Effect of Flt3 ligand gene transfer in experimental pancreatic cancer.

Authors:  E Ryschich; G Huszty; N Wentzensen; E Schmidt; H P Knaebel; J Encke; A Märten; M W Büchler; J Schmidt
Journal:  Int J Colorectal Dis       Date:  2006-03-10       Impact factor: 2.571

8.  Accumulation of DC in lamina propria induced by FMS-like tyrosine kinase 3 ligand aggravates the intestinal inflammatory response during endotoxemia.

Authors:  Xiao-song Xiang; Yun-zhao Zhao; Ning Li; Qiu-rong Li; Jie-shou Li
Journal:  Inflammation       Date:  2010-02       Impact factor: 4.092

9.  Genetic vaccination with Flt3-L and GM-CSF as adjuvants: Enhancement of cellular and humoral immune responses that results in protective immunity in a murine model of hepatitis C virus infection.

Authors:  Jens Encke; Jomo Bernardin; Jasmin Geib; Gocha Barbakadze; Raymond Bujdoso; Wolfgang Stremmel
Journal:  World J Gastroenterol       Date:  2006-11-28       Impact factor: 5.742

10.  FMS-Related Tyrosine Kinase 3 Ligand Promotes Radioresistance in Esophageal Squamous Cell Carcinoma.

Authors:  Zuoquan Zhu; Jiahang Song; Junjie Gu; Bing Xu; Xinchen Sun; Shu Zhang
Journal:  Front Pharmacol       Date:  2021-05-10       Impact factor: 5.810
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