Literature DB >> 10671239

How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1.

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Abstract

By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.

Entities:  

Year:  2000        PMID： 10671239     DOI： 10.1002/(sici)1521-3773(20000204)39:3<505::aid-anie505>3.0.co;2-b

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  23 in total

Review 1.  Theoretical predictions of drug absorption in drug discovery and development.

Authors:  Patric Stenberg; Christel A S Bergström; Kristina Luthman; Per Artursson
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

Review 2.  Bioavailability through PepT1: the role of computer modelling in intelligent drug design.

Authors:  David W Foley; Jeyaganesh Rajamanickam; Patrick D Bailey; David Meredith
Journal:  Curr Comput Aided Drug Des       Date:  2010-03       Impact factor: 1.606

3.  Comparative analysis of vertebrate PEPT1 and PEPT2 genes.

Authors:  Minghui Wang; Xiangzhe Zhang; Hongbo Zhao; Qishan Wang; Yuchun Pan
Journal:  Genetica       Date:  2009-12-20       Impact factor: 1.082

4.  Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter.

Authors:  Naomi Oshiro; Ana M Pajor
Journal:  Biochim Biophys Acta       Date:  2006-05-16

5.  In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors.

Authors:  Sean Ekins; Jeffrey S Johnston; Praveen Bahadduri; Vanessa M D'Souza; Abhijit Ray; Cheng Chang; Peter W Swaan
Journal:  Pharm Res       Date:  2005-04-07       Impact factor: 4.200

6.  Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1.

Authors:  Rikke Andersen; Flemming Steen Jørgensen; Lars Olsen; Jon Våbenø; Karina Thorn; Carsten Uhd Nielsen; Bente Steffansen
Journal:  Pharm Res       Date:  2006-02-26       Impact factor: 4.200

7.  Evidence that the rabbit proton-peptide co-transporter PepT1 is a multimer when expressed in Xenopus laevis oocytes.

Authors:  Konstantinos-E Panitsas; C A R Boyd; David Meredith
Journal:  Pflugers Arch       Date:  2006-02-08       Impact factor: 3.657

8.  Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter.

Authors:  Liya Xu; Ian S Haworth; Ashutosh A Kulkarni; Michael B Bolger; Daryl L Davies
Journal:  Pharm Res       Date:  2009-08-14       Impact factor: 4.200

9.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063

Review 10.  Review. The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence?

Authors:  David Meredith
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2009-01-27       Impact factor: 6.237
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