PURPOSE: To determine the expression pattern of multiple subtypes of cadherin adhesion receptor in postnatal mouse neural retina. METHODS: The expression of N-cadherin, R-cadherin, cadherin-6, cadherin-8, and cadherin-11 in retinas at postnatal days 0 to 42 was analyzed by in situ hybridization of mRNA as well as by immunohistochemistry. RESULTS: Each cadherin was expressed by different cell populations of the retina, and the following expression patterns were established by postnatal day 14: in the ganglion cell layer, all these molecules were expressed, but each occurred only in a subset of the cells. Likewise, in the inner nuclear layer, R-cadherin and cadherin-6 and -8 were expressed by a restricted population of amacrine cells, and cadherin-8 also by a subpopulation of bipolar cells. All horizontal cells expressed R-cadherin, and Muller cells expressed N-cadherin and cadherin-11. Proteins of R-cadherin and cadherin-6 were concentrated in neuropil layers. CONCLUSIONS: The pattern of differential expression of the five cadherins supports the idea that these molecules may play a role in selective cell interactions within the heterogeneous cell pool of the neural retina.
PURPOSE: To determine the expression pattern of multiple subtypes of cadherin adhesion receptor in postnatal mouse neural retina. METHODS: The expression of N-cadherin, R-cadherin, cadherin-6, cadherin-8, and cadherin-11 in retinas at postnatal days 0 to 42 was analyzed by in situ hybridization of mRNA as well as by immunohistochemistry. RESULTS: Each cadherin was expressed by different cell populations of the retina, and the following expression patterns were established by postnatal day 14: in the ganglion cell layer, all these molecules were expressed, but each occurred only in a subset of the cells. Likewise, in the inner nuclear layer, R-cadherin and cadherin-6 and -8 were expressed by a restricted population of amacrine cells, and cadherin-8 also by a subpopulation of bipolar cells. All horizontal cells expressed R-cadherin, and Muller cells expressed N-cadherin and cadherin-11. Proteins of R-cadherin and cadherin-6 were concentrated in neuropil layers. CONCLUSIONS: The pattern of differential expression of the five cadherins supports the idea that these molecules may play a role in selective cell interactions within the heterogeneous cell pool of the neural retina.
Authors: Amy L Wilson; Yu-Chi Shen; S G Babb-Clendenon; Jason Rostedt; Bei Liu; Kate F Barald; James A Marrs; Qin Liu Journal: Dev Dyn Date: 2007-03 Impact factor: 3.780
Authors: Jeremy N Kay; Irina De la Huerta; In-Jung Kim; Yifeng Zhang; Masahito Yamagata; Monica W Chu; Markus Meister; Joshua R Sanes Journal: J Neurosci Date: 2011-05-25 Impact factor: 6.167
Authors: Jessica A Osterhout; Nicko Josten; Jena Yamada; Feng Pan; Shaw-wen Wu; Phong L Nguyen; Georgia Panagiotakos; Yukiko U Inoue; Saki F Egusa; Bela Volgyi; Takayoshi Inoue; Stewart A Bloomfield; Ben A Barres; David M Berson; David A Feldheim; Andrew D Huberman Journal: Neuron Date: 2011-08-25 Impact factor: 17.173