Literature DB >> 10669229

Apoptosis in leukoaraiosis.

W R Brown1, D M Moody, C R Thore, V R Challa.   

Abstract

We report a case of leukoaraiosis that was studied for apoptosis. In the neuropil, the number of cells that showed DNA fragmentation was 2.5 times as great in the area of leukoaraiosis as in the adjacent white matter (P = .004) and 25 times as great as in the nearby cortex (P < .001). Our findings suggest that apoptosis, predominantly of oligodendrocytes, is involved in the pathogenesis of leukoaraiosis. Within the area of leukoaraiosis, we also found numerous small veins that were partially occluded by severe collagenous thickening of the vessel walls. This collagenosis may have contributed to or resulted from chronic ischemia in that area.

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Year:  2000        PMID： 10669229      PMCID： PMC7976327     

Source DB:  PubMed          Journal:  AJNR Am J Neuroradiol        ISSN： 0195-6108            Impact factor:   3.825


  12 in total

1.  Leukoaraiosis: correlation of MR and CT findings with blood flow, atrophy, and cognition.

Authors:  M Kobari; J S Meyer; M Ichijo; W T Oravez
Journal:  AJNR Am J Neuroradiol       Date:  1990 Mar-Apr       Impact factor: 3.825

Review 2.  Apoptosis.

Authors:  M C Cummings; C M Winterford; N I Walker
Journal:  Am J Surg Pathol       Date:  1997-01       Impact factor: 6.394

3.  Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis.

Authors:  C Stadelmann; W Brück; C Bancher; K Jellinger; H Lassmann
Journal:  J Neuropathol Exp Neurol       Date:  1998-05       Impact factor: 3.685

4.  Brain slice holder for MR.

Authors:  W R Brown; D M Moody; V P Mathews
Journal:  AJNR Am J Neuroradiol       Date:  1995-08       Impact factor: 3.825

5.  Monoclonal antibody to single-stranded DNA is a specific and sensitive cellular marker of apoptosis.

Authors:  O S Frankfurt; J A Robb; E V Sugarbaker; L Villa
Journal:  Exp Cell Res       Date:  1996-08-01       Impact factor: 3.905

6.  Neuronal apoptosis in HIV infection in adults.

Authors:  H Adle-Biassette; Y Levy; M Colombel; F Poron; S Natchev; C Keohane; F Gray
Journal:  Neuropathol Appl Neurobiol       Date:  1995-06       Impact factor: 8.090

7.  Effect of postmortem interval on in situ end-labeling of DNA oligonucleosomes.

Authors:  C K Petito; B Roberts
Journal:  J Neuropathol Exp Neurol       Date:  1995-11       Impact factor: 3.685

8.  Periventricular venous collagenosis: association with leukoaraiosis.

Authors:  D M Moody; W R Brown; V R Challa; R L Anderson
Journal:  Radiology       Date:  1995-02       Impact factor: 11.105

9.  Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

Authors:  Y Gavrieli; Y Sherman; S A Ben-Sasson
Journal:  J Cell Biol       Date:  1992-11       Impact factor: 10.539

Review 10.  Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.

Authors:  J F Kerr; A H Wyllie; A R Currie
Journal:  Br J Cancer       Date:  1972-08       Impact factor: 7.640
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  14 in total

1.  Microvascular changes in the white mater in dementia.

Authors:  William R Brown; Dixon M Moody; Clara R Thore; John A Anstrom; Venkata R Challa
Journal:  J Neurol Sci       Date:  2009-03-05       Impact factor: 3.181

2.  Cerebral white matter hyperintensity in African Americans and European Americans with type 2 diabetes.

Authors:  Jasmin Divers; Christina Hugenschmidt; Kaycee M Sink; Jeffrey D Williamson; Yaorong Ge; S Carrie Smith; Donald W Bowden; Christopher T Whitlow; Eric Lyders; Joseph A Maldjian; Barry I Freedman
Journal:  J Stroke Cerebrovasc Dis       Date:  2012-05-16       Impact factor: 2.136

3.  Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance.

Authors:  R Bruening; M Dichgans; C Berchtenbreiter; T Yousry; K C Seelos; R H Wu; M Mayer; G Brix; M Reiser
Journal:  AJNR Am J Neuroradiol       Date:  2001-08       Impact factor: 3.825

Review 4.  Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

Authors:  Rebecca Parodi-Rullán; Je Yeong Sone; Silvia Fossati
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472

5.  Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well.

Authors:  William R Brown; Dixon M Moody; Clara R Thore; Venkata R Challa; John A Anstrom
Journal:  J Neurol Sci       Date:  2007-02-23       Impact factor: 3.181

6.  Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss.

Authors:  J J Kril; S Patel; A J Harding; G M Halliday
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-06       Impact factor: 10.154

Review 7.  Review: cerebral microvascular pathology in ageing and neurodegeneration.

Authors:  W R Brown; C R Thore
Journal:  Neuropathol Appl Neurobiol       Date:  2011-02       Impact factor: 8.090

8.  Automated white matter total lesion volume segmentation in diabetes.

Authors:  J A Maldjian; C T Whitlow; B N Saha; G Kota; C Vandergriff; E M Davenport; J Divers; B I Freedman; D W Bowden
Journal:  AJNR Am J Neuroradiol       Date:  2013-07-18       Impact factor: 3.825

9.  Whole-brain histogram and voxel-based analyses of diffusion tensor imaging in patients with leukoaraiosis: correlation with motor and cognitive impairment.

Authors:  R Della Nave; S Foresti; A Pratesi; A Ginestroni; M Inzitari; E Salvadori; M Giannelli; S Diciotti; D Inzitari; M Mascalchi
Journal:  AJNR Am J Neuroradiol       Date:  2007-08       Impact factor: 3.825

10.  Diffusion tensor tractography in cerebral small vessel disease: correlation with cognitive function.

Authors:  Maria M D'Souza; S P Gorthi; Kunal Vadwala; Richa Trivedi; C Vijayakumar; Prabhjot Kaur; Subash Khushu
Journal:  Neuroradiol J       Date:  2017-10-13
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