Literature DB >> 10668400

HIV protease: enzyme function and drug resistance.

S Gulnik1, J W Erickson, D Xie.   

Abstract

HIV protease is responsible for processing of the gag and gag-pol polyproteins during virion maturation. The activity of this enzyme is essential for virus infectivity, rendering the protein a major therapeutic target for AIDS treatment. This articles reviews the biochemical and biophysical properties of the enzyme. The clinical and in vitro observations of resistance to protease inhibitors are discussed from the perspective of drug resistance mechanisms of HIV protease mutants.

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Year:  2000        PMID： 10668400     DOI： 10.1016/s0083-6729(00)58026-1

Source DB:  PubMed          Journal:  Vitam Horm        ISSN： 0083-6729            Impact factor:   3.421


  9 in total

1.  Structure-based phenotyping predicts HIV-1 protease inhibitor resistance.

Authors:  Mark D Shenderovich; Ron M Kagan; Peter N R Heseltine; Kal Ramnarayan
Journal:  Protein Sci       Date:  2003-08       Impact factor: 6.725

2.  Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance.

Authors:  S Alireza Rabi; Gregory M Laird; Christine M Durand; Sarah Laskey; Liang Shan; Justin R Bailey; Stanley Chioma; Richard D Moore; Robert F Siliciano
Journal:  J Clin Invest       Date:  2013-08-27       Impact factor: 14.808

3.  A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.

Authors:  Kazuhisa Yoshimura; Ryohei Kato; Mark F Kavlick; Aline Nguyen; Victor Maroun; Kenji Maeda; Khaja A Hussain; Arun K Ghosh; Sergei V Gulnik; John W Erickson; Hiroaki Mitsuya
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

4.  Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations.

Authors:  Stefano Piana; Paolo Carloni; Ursula Rothlisberger
Journal:  Protein Sci       Date:  2002-10       Impact factor: 6.725

5.  The folding free-energy surface of HIV-1 protease: insights into the thermodynamic basis for resistance to inhibitors.

Authors:  Amanda F Noel; Osman Bilsel; Agnita Kundu; Ying Wu; Jill A Zitzewitz; C Robert Matthews
Journal:  J Mol Biol       Date:  2009-01-06       Impact factor: 5.469

Review 6.  Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell Death.

Authors:  Ana C Paim; Andrew D Badley; Nathan W Cummins
Journal:  AIDS Res Hum Retroviruses       Date:  2019-12-10       Impact factor: 2.205

Review 7.  Mesenchymal Stromal Cells: a Possible Reservoir for HIV-1?

Authors:  K Kallmeyer; M A Ryder; M S Pepper
Journal:  Stem Cell Rev Rep       Date:  2022-01-01       Impact factor: 6.692

8.  Combining Molecular Dynamic Information and an Aspherical-Atom Data Bank in the Evaluation of the Electrostatic Interaction Energy in Multimeric Protein-Ligand Complex: A Case Study for HIV-1 Protease.

Authors:  Prashant Kumar; Paulina Maria Dominiak
Journal:  Molecules       Date:  2021-06-24       Impact factor: 4.411

Review 9.  Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade.

Authors:  Luca Perico; Ariela Benigni; Giuseppe Remuzzi
Journal:  Nephron       Date:  2020-03-23       Impact factor: 2.847
  9 in total

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