| Literature DB >> 10668177 |
S Nacak1, D S Doğruer, M F Sahin.
Abstract
Eight (1-benzyl-2(3H)-benzimidazolon-3-yl)acetic acid derivatives have been synthesized and tested for antinociceptive activity in this study. All compounds but one, at the oral dose of 100 mg/kg were comparable with aspirin. Ethyl (1-benzyl-2(3H)-benzimidazolon-3-yl)acetate (3), 4-[(1-benzyl-2(3H)-benzimidazolon-3-yl)acetyl]morpholine (6a) and 1-[(1-benzyl-2(3H)-benzimidazolon-3-yl)acetyl]pyrrolidine (6b) have shown more potent antinociceptive activity than others.Entities:
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Year: 1999 PMID： 10668177 DOI： 10.1016/s0014-827x(99)00100-7
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X