Noninvasive assessment of left ventricular systolic function by stress-shortening relation, rate of change of power, preload-adjusted maximal power, and ejection force in idiopathic dilated cardiomyopathy: prognostic implications.

Indexes of left ventricular systolic function that are considered relatively load-insensitive were assessed to determine their relation to the severity of heart failure symptoms and their ability to predict the outcome of idiopathic dilated cardiomyopathy. Stress, flow, power, and ejection force were calculated throughout ejection by echocardiography at rest in 35 patients with idiopathic dilated cardiomyopathy and in 20 control subjects. Patients were evaluated prospectively every 6 months for 2 years. Asymptomatic patients were separated most clearly from New York Heart Association (NYHA) class II by end-systolic stress; NYHA class II patients were separated from NYHA class III and the latter from NYHA class IV by peak rate of change of flow. Ten patients showed improvement in symptoms as well as in systolic indexes; none of them died during the follow-up. Improvement was unpredictable with the evaluated variables. One- and 2-year cardiovascular mortality rates were 17% and 26%, respectively. Patients whose condition did not improve after the first year had a 17% second-year mortality rate. Peak rate of change of power predicted death with 100% sensitivity, 56% specificity, and 64% positive predictive value in NYHA III and IV patients.