| Literature DB >> 10667898 |
S Kageyama1, J K Maniar, M Iwasaki, J Zhang, D G Saple, H Tsuchie, A Tanabe-Tochikura, K Taniguchi, K Shiraki, T Kurimura.
Abstract
The discordant cases of seronegative, but culture and proviral HIV-2 DNA positive were found in Mumbai, India. This was corroborated by the successful isolation of HIV-2-RNA in culture medium, HIV-2 cDNA sequence determination and the detection of the antigen. The sequence of the isolated HIV-2 genomic RNA does not seem to be altered to the extent that the change will alter antibody binding. Furthermore, antibody from the same individual (even at 8 months from initial sampling) from whom HIV-2 was isolated did not react with the antigen of this strain. Those evidences imply that extremely low or non-production of the antibody may be due to suboptimal immune stimulation due to extremely slow HIV-2 replication. This low virus-load may be responsible for the negative antibody results in the HIV-2 carriers.Entities:
Keywords: Antibodies; Antigens; Asia; Biology; Clinical Research; Developing Countries; Diseases; Examinations And Diagnoses; Hiv Infections; Hiv Serodiagnosis; Immunity; Immunologic Factors; India; Laboratory Examinations And Diagnoses; Physiology; Research Methodology; Research Report; Southern Asia; Viral Diseases
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Year: 2000 PMID： 10667898 DOI： 10.1258/0956462001914878
Source DB: PubMed Journal: Int J STD AIDS ISSN： 0956-4624 Impact factor: 1.359