Literature DB >> 10666742

Oligomerization of deoxyguanosine 5'-phosphoro-2-methylimidazolide on a polycytidylate template.

I A Kozlov1, L E Orgel.   

Abstract

The oligomerization of deoxyguanosine 5'-phosphoro-2-methylimidazolide on a polycytidylate template is much less efficient than the oligomerization of the corresponding activated ribonucleotide. Nonetheless oligomers containing up to eight nucleotide residues are detected. The products are 3'-5'-linked oligodeoxyribonucleotides capped at the 5'-terminus with a pyrophosphate-linked monomer.

Entities:  

Keywords:  NASA Discipline Exobiology; Non-NASA Center

Mesh：

Substances：

Year:  1999        PMID： 10666742     DOI： 10.1023/a:1006666926870

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN： 0169-6149            Impact factor:   1.950


  7 in total

1.  Reactions of adenosine 5'phosphorimidazolide with adenosine analogs on a polyuridylic acid template.

Authors:  R Lohrmann; L E Orgel
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

2.  Specificity of template-directed synthesis with adenine nucleosides.

Authors:  H Schneider-Bernloehr; R Lohrmann; J Sulston; L E Orgel; H T Miles
Journal:  J Mol Biol       Date:  1970-01-28       Impact factor: 5.469

3.  Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure.

Authors:  I A Kozlov; P K Politis; A Van Aerschot; R Busson; P Herdewijn; L E Orgel
Journal:  J Am Chem Soc       Date:  1999-03-31       Impact factor: 15.419

4.  Nonenzymatic template-directed synthesis on oligodeoxycytidylate sequences in hairpin oligonucleotides.

Authors:  T Wu; L E Orgel
Journal:  J Am Chem Soc       Date:  1992       Impact factor: 15.419

5.  Kinetic preference for the 3'-5'-linked dimer in the reaction of guanosine 5'-phosphorylmorpholinamide with deoxyguanosine 5'-phosphoryl-2-methylimidazolide as a function of poly(C) concentration.

Authors:  A Kanavarioti
Journal:  J Org Chem       Date:  1998-10-02       Impact factor: 4.354

6.  Selective cleavage of pyrophosphate linkages.

Authors:  J Visscher; A W Schwartz
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

7.  Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.

Authors:  G F Joyce; T Inoue; L E Orgel
Journal:  J Mol Biol       Date:  1984-06-25       Impact factor: 5.469
  7 in total

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