Literature DB >> 10666613

Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis.

I Li de la Sierra1, H Munier-Lehmann, A M Gilles, O Bârzu, M Delarue.   

Abstract

Mycobacterium tuberculosis thymidylate kinase complexed with the substrate deoxythymidine monophosphate was crystallized in the hexagonal space group P6(5)22 or P6(1)22, with unit-cell parameters a = b = 76.62, c = 134.38 A and one single monomer of 23 kDa in the asymmetric unit. Cryo-cooled crystals diffract at 1.94 A resolution using synchrotron radiation.

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Year:  2000        PMID： 10666613     DOI： 10.1107/s0907444999016212

Source DB:  PubMed          Journal:  Acta Crystallogr D Biol Crystallogr        ISSN： 0907-4449


  2 in total

1.  Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Authors:  Vladimir Frecer; Pierfausto Seneci; Stanislav Miertus
Journal:  J Comput Aided Mol Des       Date:  2010-11-17       Impact factor: 3.686

2.  Characterization of Streptococcus pneumoniae thymidylate kinase: steady-state kinetics of the forward reaction and isothermal titration calorimetry.

Authors:  Chantal M Petit; Kristin K Koretke
Journal:  Biochem J       Date:  2002-05-01       Impact factor: 3.857
  2 in total

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