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Literature DB >> 10666279

Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor.

K M Haan¹, W W Kwok, R Longnecker, P Speck.

Abstract

Epstein-Barr virus (EBV) glycoprotein gp350/gp220 association with cellular CD21 facilitates virion attachment to B lymphocytes. Membrane fusion requires the additional interaction between virion gp42 and cellular HLA-DR. This binding is thought to catalyze membrane fusion through a further association with the gp85-gp25 (gH-gL) complex. Cell lines expressing CD21 but lacking expression of HLA class II molecules are resistant to infection by a recombinant EBV expressing enhanced green fluorescent protein. Surface expression of HLA-DR, HLA-DP, or HLA-DQ confers susceptibility to EBV infection on resistant cells that express CD21. Therefore, HLA-DP or HLA-DQ can substitute for HLA-DR and serve as a coreceptor in EBV entry.

Entities: Chemical Disease Gene Species

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Year: 2000 PMID： 10666279 PMCID： PMC111730 DOI： 10.1128/jvi.74.5.2451-2454.2000

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

31 in total

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Journal: J Virol Date: 1995-07 Impact factor: 5.103

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51 in total

1. Everyone comes from somewhere: systemic lupus erythematosus and Epstein-Barr virus induction of host interferon and humoral anti-Epstein-Barr nuclear antigen 1 immunity.

Authors: John B Harley; Judith A James
Journal: Arthritis Rheum Date: 2010-06

2. Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells.

Authors: Timothy E Quan; Robert M Roman; Benjamin J Rudenga; V Michael Holers; Joseph E Craft
Journal: Arthritis Rheum Date: 2010-06

3. Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion.

Authors: Austin N Kirschner; Jasmina Omerovic; Boris Popov; Richard Longnecker; Theodore S Jardetzky
Journal: J Virol Date: 2006-10 Impact factor: 5.103

4. Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry.

Authors: Claude Krummenacher; Vinit M Supekar; J Charles Whitbeck; Eric Lazear; Sarah A Connolly; Roselyn J Eisenberg; Gary H Cohen; Don C Wiley; Andrea Carfí
Journal: EMBO J Date: 2005-11-17 Impact factor: 11.598

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Authors: R Jiang; R S Scott; L M Hutt-Fletcher
Journal: J Virol Date: 2006-07 Impact factor: 5.103

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Authors: Austin N Kirschner; Amanda S Lowrey; Richard Longnecker; Theodore S Jardetzky
Journal: J Virol Date: 2007-06-20 Impact factor: 5.103