R Ojala1, S Ikonen, O Tammela. 1. Department of Paediatrics, Tampere University Hospital, P.O. Box 2000, 33521 Tampere, Finland.
Abstract
UNLABELLED: To evaluate the incidence of neonatal complications among infants exposed to indomethacin antenatally, postnatally or both ante-and postnatally (combined), the records of 240 infants of gestational ages between 23 to 32 weeks were analysed retrospectively. Antenatal indomethacin treatment for longer than 2 days with a daily or cumulative dosage >/=150 mg correlated with a significantly higher incidence of grade I-II intraventricular haemorrhage. Combined exposure, cumulative antenatal exposure >/=150 mg and duration of antenatal exposure of more than 2 days was associated with necrotising enterocolitis and a cumulative exposure with sepsis. There was no independent association between indomethacin exposure and pneumothorax, bronchopulmonary dysplasia or respiratory distress syndrome. CONCLUSION: Preterm infants with exposure to antenatal indomethacin might be at increased risk of grade I and II intraventricular haemorrhage and those with both ante- and postnatal exposure at an increased risk of necrotising enterocolitis and sepsis.
UNLABELLED: To evaluate the incidence of neonatal complications among infants exposed to indomethacin antenatally, postnatally or both ante-and postnatally (combined), the records of 240 infants of gestational ages between 23 to 32 weeks were analysed retrospectively. Antenatal indomethacin treatment for longer than 2 days with a daily or cumulative dosage >/=150 mg correlated with a significantly higher incidence of grade I-II intraventricular haemorrhage. Combined exposure, cumulative antenatal exposure >/=150 mg and duration of antenatal exposure of more than 2 days was associated with necrotising enterocolitis and a cumulative exposure with sepsis. There was no independent association between indomethacin exposure and pneumothorax, bronchopulmonary dysplasia or respiratory distress syndrome. CONCLUSION: Preterm infants with exposure to antenatal indomethacin might be at increased risk of grade I and II intraventricular haemorrhage and those with both ante- and postnatal exposure at an increased risk of necrotising enterocolitis and sepsis.
Authors: R Ojala; M Ala-Houhala; S Ahonen; A Harmoinen; V Turjanmaa; S Ikonen; O Tammela Journal: Arch Dis Child Fetal Neonatal Ed Date: 2001-01 Impact factor: 5.747
Authors: Melanie Vogel; Louise E Wilkins-Haug; Doff B McElhinney; Audrey C Marshall; Carol B Benson; Virginia Silva; Wayne Tworetzky Journal: Fetal Diagn Ther Date: 2009-12-17 Impact factor: 2.587