Literature DB >> 10662699

The importance of being r: greater oxidative stability of RNA compared with DNA.

H H Thorp1.   

Abstract

The 2'-hydroxyl group of ribose imparts hydrolytic lability on RNA, which provides a mechanism for numerous biological functions. Recent evidence from chemical cleavage studies shows that this hydroxyl group also stabilizes the sugar moiety in RNA towards oxidation relative to DNA. Is this just because RNA needs to be distinguishable from DNA or does it have other evolutionary significance?

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Year:  2000        PMID： 10662699     DOI： 10.1016/s1074-5521(00)00080-6

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  11 in total

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