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Literature DB >> 10660083

Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.

T Konoshima¹, M Takasaki, E Ichiishi, T Murakami, H Tokuda, H Nishino, N M Duc, R Kasai, K Yamasaki.

Abstract

In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Panax plants were screened. Consequently, the ocotillol-type saponin, majonoside-R2 (MR2), was obtained from the rhizome and root of Panax vietnamensis (Vietnamese ginseng) as an active constituent. MR2 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. Further, MR2 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin induced by nitric oxide (NO) donor/12-O-tetradecanoylphorbol-13-acetate (TPA) or peroxynitrite/TPA.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1999 PMID： 10660083 DOI： 10.1016/s0304-3835(99)00257-8

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

8 in total

1. De novo whole-genome assembly and discovery of genes involved in triterpenoid saponin biosynthesis of Vietnamese ginseng (Panax vietnamensis Ha et Grushv.).

Authors: Nguyen Quang Duc Tien; Xiao Ma; Le Quang Man; Duong Thi Kim Chi; Nguyen Xuan Huy; Duong-Tan Nhut; Stephane Rombauts; Tran Ut; Nguyen Hoang Loc
Journal: Physiol Mol Biol Plants Date: 2021-10-11

2. Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action.

Authors: Subhasree Ashok Nag; Jiang-Jiang Qin; Wei Wang; Ming-Hai Wang; Hui Wang; Ruiwen Zhang
Journal: Front Pharmacol Date: 2012-02-28 Impact factor: 5.810

3. In silico studies for the interaction of tumor necrosis factor-alpha (TNF-α) with different saponins from Vietnamese ginseng (Panax vietnamesis).

Authors: Oanh T P Kim; Manh D Le; Hoang X Trinh; Hai V Nong
Journal: Biophys Physicobiol Date: 2016-07-14

8. Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers.

Authors: Guang-Hui Zhang; Chun-Hua Ma; Jia-Jin Zhang; Jun-Wen Chen; Qing-Yan Tang; Mu-Han He; Xiang-Zeng Xu; Ni-Hao Jiang; Sheng-Chao Yang
Journal: BMC Genomics Date: 2015-03-08 Impact factor: 3.969

8 in total

Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.

1. De novo whole-genome assembly and discovery of genes involved in triterpenoid saponin biosynthesis of Vietnamese ginseng (Panax vietnamensis Ha et Grushv.).

2. Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action.

3. In silico studies for the interaction of tumor necrosis factor-alpha (TNF-α) with different saponins from Vietnamese ginseng (Panax vietnamesis).

Review 4. Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.

5. Accumulation of Saponins in Underground Parts of Panax vietnamensis at Different Ages Analyzed by HPLC-UV/ELSD.

6. Identification of floral scent in chrysanthemum cultivars and wild relatives by gas chromatography-mass spectrometry.

Review 7. Recent Advances in the Semisynthesis, Modifications and Biological Activities of Ocotillol-Type Triterpenoids.

8. Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers.