Comparative pathogenesis of enteric viral infections of swine.

At least 11 enteric viruses belonging to 6 distinct families (Adenoviridae, Astroviridae, Caliciviridae, Coronaviridae, Parvoviridae, and Reoviridae) cause diarrhea in swine mainly during the nursing and immediate post-weaning period. Most infect the small intestinal enterocytes, inducing various degrees of villous atrophy and subsequently a malabsorptive, maldigestive diarrhea. In addition rotaviruses possess an enterotoxin (NSP4) which induces a secretory diarrhea in mice. These viruses have distinct predilections for different vertical (villus/crypt) and horizontal (duodenum, jejunum, ileum, colon) replication sites in the intestine and the diarrhea intensity is often related to the extent of viral replication at these sites. In addition concurrent infections with multiple enteric viruses can produce synergistic or additive effects leading to more extensive villous atrophy throughout the intestine and more severe and prolonged diarrhea. Knowledge of enteric viral replication sites and comparative mechanisms of diarrhea induction may lead to new or improved vaccine strategies or therapeutic approaches for the prevention or treatment of these viral diarrheas.