OBJECTIVE: The aim of this study was to clarify the relationship between morphologic changes of the pituitary gland and the genotype of Prophet of Pit-1 (PROP1), a newly discovered gene responsible for congenital combined pituitary hormone deficiency, in a series of eight humans with this disorder. CONCLUSION: Congenital hypoplasia of the anterior pituitary gland is the most common MR imaging finding in patients with combined pituitary hormone deficiency. Our findings suggest a crucial role for PROP1 in pituitary organogenesis as well as anterior pituitary cell differentiation.
OBJECTIVE: The aim of this study was to clarify the relationship between morphologic changes of the pituitary gland and the genotype of Prophet of Pit-1 (PROP1), a newly discovered gene responsible for congenital combined pituitary hormone deficiency, in a series of eight humans with this disorder. CONCLUSION:Congenital hypoplasia of the anterior pituitary gland is the most common MR imaging finding in patients with combined pituitary hormone deficiency. Our findings suggest a crucial role for PROP1 in pituitary organogenesis as well as anterior pituitary cell differentiation.
Authors: A Voutetakis; A Sertedaki; S Livadas; P Xekouki; I Bossis; C Dacou-Voutetakis; M I Argyropoulou Journal: J Endocrinol Invest Date: 2006-05 Impact factor: 4.256
Authors: L L F do Amaral; R M Ferreira; N P F D Ferreira; R A Mendonça; V H R Marussi; J L da Cunha; B R Maçaranduba; J D Medeiros Journal: AJNR Am J Neuroradiol Date: 2007-08 Impact factor: 3.825
Authors: F Castinetti; R Reynaud; M-H Quentien; N Jullien; E Marquant; C Rochette; J-P Herman; A Saveanu; A Barlier; A Enjalbert; T Brue Journal: J Endocrinol Invest Date: 2014-09-09 Impact factor: 4.256
Authors: Daniel Kelberman; Karine Rizzoti; Robin Lovell-Badge; Iain C A F Robinson; Mehul T Dattani Journal: Endocr Rev Date: 2009-10-16 Impact factor: 19.871