| Literature DB >> 10658593 |
J Bonjoch1, F Diaba, G Puigbó, D Solé, V Segarra, L Santamaría, J Beleta, H Ryder, J M Palacios.
Abstract
The synthesis of an azaspirocyclic analogue of FR901483, phosphate 2, is described based on the implementation of a key 5-endo aminocyclization promoted by iodine for direct functionalization of the 1-azaspiro[4.5]decane ring at the C-3 atom. Compound 2 has no inhibitory activity in the cell proliferation assays reported.Entities:
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Year: 1999 PMID： 10658593 DOI： 10.1016/s0968-0896(99)00250-3
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641