| Literature DB >> 10658579 |
P Allevi1, A Longo, M Anastasia.
Abstract
Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4''-hydroxy groups, methylation of the resulting 2',4''-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.Entities:
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Year: 1999 PMID： 10658579 DOI： 10.1016/s0968-0896(99)00230-8
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641