Literature DB >> 10658235

The use of eardrops in an ENT department.

S Natsch1, E A Mylanus, J J Mulder, Y A Hekster.   

Abstract

A survey of the pattern of usage of ototopical preparations in out-patients of the ENT department of a Dutch University Hospital has been performed. Data on clinical presentation and previous treatment of the patient, otoscopic results, prescribed current treatment and, if available, results of microbiological examination were collected. One-hundred and twenty-one evaluable patients were prospectively included. For 20% of the patients it concerned a first manifestation of the symptoms, 35% had a recurrence after a period free of symptoms and in 37% it concerned patients with persisting symptoms despite treatment. Forty-five percent of the patients' ears concerned had an intact tympanic membrane, in 25% a perforation was present and in 12% middle ear ventilation tubes were in situ. Thirty-five percent had already received previous treatment with ear drops. The species most often isolated was Staphylococcus aureus, followed by Pseudomonas aeruginosa. A wide range of products were prescribed. While previous treatment occurred with combination preparations, for current prescriptions, ofloxacin was most often used. Most patients received 2 to 3 drops 3 times a day for 7 to 10 days, which is in accordance with recommendations in the literature. Potentially ototoxic substances are regularly used in daily practice. Ofloxacin is widely used even thought it is not registered for this indication in the Netherlands and the development of resistance has to be taken into account. A new policy based on this survey is proposed, which will reduce the number of different preparations used and will eliminate ofloxacin from first the treatment.

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Year:  1999        PMID: 10658235     DOI: 10.1023/a:1008712422891

Source DB:  PubMed          Journal:  Pharm World Sci        ISSN: 0928-1231


  21 in total

1.  Susceptibility of corneal and conjunctival pathogens to ciprofloxacin.

Authors:  H P Knauf; R Silvany; P M Southern; R C Risser; S E Wilson
Journal:  Cornea       Date:  1996-01       Impact factor: 2.651

2.  Safety of topical ear drops containing ototoxic antibiotics.

Authors:  Y Rakover; K Keywan; G Rosen
Journal:  J Otolaryngol       Date:  1997-06

Review 3.  Clinical ototoxicity of topical antibiotic drops.

Authors:  P S Roland
Journal:  Otolaryngol Head Neck Surg       Date:  1994-06       Impact factor: 3.497

4.  High frequency hearing loss associated with otitis media.

Authors:  L L Hunter; R H Margolis; J R Rykken; C T Le; K A Daly; G S Giebink
Journal:  Ear Hear       Date:  1996-02       Impact factor: 3.570

5.  Ototoxicity of ear drops in patients suffering from chronic otitis media.

Authors:  L Podoshin; M Fradis; J Ben David
Journal:  J Laryngol Otol       Date:  1989-01       Impact factor: 1.469

6.  Do aminoglycoside otic preparations cause ototoxicity in the presence of tympanic membrane perforations?

Authors:  D L Wong; J A Rutka
Journal:  Otolaryngol Head Neck Surg       Date:  1997-03       Impact factor: 5.591

7.  Therapeutic management of chronic suppurative otitis media with otic drops.

Authors:  D O Merifield; N J Parker; N C Nicholson
Journal:  Otolaryngol Head Neck Surg       Date:  1993-07       Impact factor: 3.497

8.  Safety of ototopical antibiotics.

Authors:  D B Welling; L A Forrest; F Goll
Journal:  Laryngoscope       Date:  1995-05       Impact factor: 3.325

9.  Allergy due to topical medications in chronic otitis externa and chronic otitis media.

Authors:  C J Van Ginkel; T D Bruintjes; E H Huizing
Journal:  Clin Otolaryngol Allied Sci       Date:  1995-08

10.  Ototoxicity and ototopical medications: a survey of otolaryngologists.

Authors:  L B Lundy; M D Graham
Journal:  Am J Otol       Date:  1993-03
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