Literature DB >> 10657837

Defective inactivation of leukotriene B4 in patients with Sjögren-Larsson syndrome.

M A Willemsen1, J G de Jong, P H van Domburg, J J Rotteveel, R J Wanders, E Mayatepek.   

Abstract

In 6 patients with Sjögren-Larsson syndrome (SLS), the urinary excretion of leukotriene B(4) (LTB(4)) and omega-hydroxy-LTB(4) was found to be highly elevated, whereas omega-carboxy-LTB(4) was absent. This abnormal pattern of urinary excretion of LTB(4) and its metabolites appears to be unique to patients with SLS and offers a new approach to the diagnosis of this disorder. Moreover, defective inactivation of LTB(4) might be of pathophysiologic significance in the disease.

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Year:  2000        PMID： 10657837     DOI： 10.1016/s0022-3476(00)70113-2

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  9 in total

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Review 4.  Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.

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Review 7.  Fatty aldehyde and fatty alcohol metabolism: review and importance for epidermal structure and function.

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Journal:  Biochim Biophys Acta       Date:  2013-09-12

8.  The role of fatty aldehyde dehydrogenase in epidermal structure and function.

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Review 9.  Sjogren-Larsson Syndrome: Mechanisms and Management.

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  9 in total

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