Literature DB >> 10657070

The potential of BACE inhibitors for Alzheimer's therapy.

H Potter1, D Dressler.   

Abstract

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Year:  2000        PMID： 10657070     DOI： 10.1038/72477

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  2 in total

1.  Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.

Authors:  S Kitazume; Y Tachida; R Oka; K Shirotani; T C Saido; Y Hashimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-06       Impact factor: 11.205

2.  Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.

Authors:  Arun K Ghosh; Nagaswamy Kumaragurubaran; Lin Hong; Sarang Kulkarni; Xiaoming Xu; Heather B Miller; Dandepally Srinivasa Reddy; Vajira Weerasena; Robert Turner; Wanpin Chang; Gerald Koelsch; Jordan Tang
Journal:  Bioorg Med Chem Lett       Date:  2008-01-03       Impact factor: 2.823
  2 in total

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