AIMS: To assess the possible contribution of a genetic factor to diabetic retinopathy. METHODS: (CA)n repeat length was investigated in the 5' upstream region of the gene coding for aldose reductase (AR), which is a key enzyme of the polyol pathway and plays a role in hyperglycaemia-induced tissue damage, in Japanese patients with Type 2 DM. RESULTS: The dinucleotide repeat length was significantly associated with proliferative diabetic retinopathy (PDR) (P= 0.029, Mann-Whitney U-test); i.e. shorter alleles were more prevalent in the PDR group than in the control group. CONCLUSIONS: (CA)n repeat length, rather than a specific allele, in the 5' upstream region of the AR gene is associated with diabetic retinopathy. These data suggest that the AR locus plays a role in genetic susceptibility to diabetic retinopathy and that dinucleotide repeats in genomic DNA may be related to disease predisposition.
AIMS: To assess the possible contribution of a genetic factor to diabetic retinopathy. METHODS: (CA)n repeat length was investigated in the 5' upstream region of the gene coding for aldose reductase (AR), which is a key enzyme of the polyol pathway and plays a role in hyperglycaemia-induced tissue damage, in Japanese patients with Type 2 DM. RESULTS: The dinucleotide repeat length was significantly associated with proliferative diabetic retinopathy (PDR) (P= 0.029, Mann-Whitney U-test); i.e. shorter alleles were more prevalent in the PDR group than in the control group. CONCLUSIONS: (CA)n repeat length, rather than a specific allele, in the 5' upstream region of the AR gene is associated with diabetic retinopathy. These data suggest that the AR locus plays a role in genetic susceptibility to diabetic retinopathy and that dinucleotide repeats in genomic DNA may be related to disease predisposition.
Authors: C L Galindo; J F McCormick; V J Bubb; D H Abid Alkadem; Long-Shan Li; L J McIver; A C George; D A Boothman; J P Quinn; M A Skinner; H R Garner Journal: Breast Cancer Res Treat Date: 2010-12-10 Impact factor: 4.872
Authors: Cristi L Galindo; Lauren J McIver; Hongseok Tae; John F McCormick; Michael A Skinner; Ina Hoeschele; Cheryl M Lewis; John D Minna; David A Boothman; Harold R Garner Journal: Genes Chromosomes Cancer Date: 2011-01-14 Impact factor: 5.006