M E Mullins1, C L Brands, M R Daya. 1. Oregon Poison Center, Department of Emergency Medicine, Oregon Health Sciences Center, Portland, Oregon, USA. mullinsm@msnotes.wustl.edu
Abstract
OBJECTIVE: To determine whether routine follow-up coagulation studies are useful in children with accidental exposures to rodenticides containing superwarfarin compounds. DESIGN: Retrospective review of poison center charts involving pediatric superwarfarin exposures occurring in two 2-year periods. SETTING: An American Association of Poison Control Centers-certified regional poison control center with an annual call volume of 55 000 calls per year from a 2-state area with a combined population of 4 million people. OUTCOME MEASURES: Prothrombin times and/or international normalized ratios and reported clinical signs of excessive anticoagulation after exposure. RESULTS: Of 542 children in 4 years of data collection, follow-up prothrombin times and/or international normalized ratios measurements did not detect any significant coagulation abnormalities. No child developed bleeding complications. No child required or received antidotal treatment with vitamin K. CONCLUSION: Normal preschool-aged children with unintentional acute exposures to superwarfarin rodenticides do not require any routine follow-up laboratory studies and do not require any medical intervention.
OBJECTIVE: To determine whether routine follow-up coagulation studies are useful in children with accidental exposures to rodenticides containing superwarfarin compounds. DESIGN: Retrospective review of poison center charts involving pediatric superwarfarin exposures occurring in two 2-year periods. SETTING: An American Association of Poison Control Centers-certified regional poison control center with an annual call volume of 55 000 calls per year from a 2-state area with a combined population of 4 million people. OUTCOME MEASURES: Prothrombin times and/or international normalized ratios and reported clinical signs of excessive anticoagulation after exposure. RESULTS: Of 542 children in 4 years of data collection, follow-up prothrombin times and/or international normalized ratios measurements did not detect any significant coagulation abnormalities. No child developed bleeding complications. No child required or received antidotal treatment with vitamin K. CONCLUSION: Normal preschool-aged children with unintentional acute exposures to superwarfarin rodenticides do not require any routine follow-up laboratory studies and do not require any medical intervention.