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Literature DB >> 1065448

Familial cancer on a Scottish island.

Abstract

When the causes of death were determined in 18 relations of a child with Fanconi's anaemia 10 deaths were found to be due to carcinoma of various organs. Cases of osteogenic sarcoma, leukaemia, and Marfan's syndrome were also discovered among relatives. The family was from a remote community in the hebrides and there was considerable intermarriage. Suggestive evidence of heterozygosity was found by chromosome analysis.

Entities: Disease Species

Mesh：

Year: 1976 PMID： 1065448 PMCID： PMC1687524 DOI： 10.1136/bmj.2.6032.401

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

8 in total

1. The incidence of leukemia in families of patients with hypoplasia of the marrow.

Authors: S GARRIGA; W H CROSBY
Journal: Blood Date: 1959-09 Impact factor: 22.113

2. Population structure of Barra (Outer Hebrides).

Authors: N E Morton; C Smith; R Hill; A Frackiewicz; P Law; S Yee
Journal: Ann Hum Genet Date: 1976-01 Impact factor: 1.670

3. Leukemia in Fanconi's anemia: cytogenetic and tumor virus susceptibility studies.

Authors: H Dosik; L Y Hsu; G J Todaro; S L Lee; K Hirschhorn; E S Selirio; A A Alter
Journal: Blood Date: 1970-09 Impact factor: 22.113

4. Fanconi's anaemia in the genetics of neoplasia.

Authors: M Swift
Journal: Nature Date: 1971-04-09 Impact factor: 49.962

5. Squamous cell carcinomas in Fanconi's anemia.

Authors: M Swift; D Zimmerman; E R McDonough
Journal: JAMA Date: 1971-04-12 Impact factor: 56.272

Review 6. Genetic factors in the etiology of cancer.

Authors: W E Heston
Journal: Cancer Res Date: 1965-09 Impact factor: 12.701

7. Spontaneous chromosomal breakage and high incidence of leukemia in inherited disease.

Authors: T M Schroeder; R Kurth
Journal: Blood Date: 1971-01 Impact factor: 22.113

8. The influence of chemotherapy on survival in acute leukemia. 3. A comparison of patients treated during 1958-1964 with those treated in two sequentially preceding periods.

Authors: A Mangalik; D R Boggs; M M Wintrobe; G E Cartwright
Journal: Blood Date: 1966-04 Impact factor: 22.113

8 in total

4 in total

Familial cancer on a Scottish island.

1. The incidence of leukemia in families of patients with hypoplasia of the marrow.

2. Population structure of Barra (Outer Hebrides).

3. Leukemia in Fanconi's anemia: cytogenetic and tumor virus susceptibility studies.

4. Fanconi's anaemia in the genetics of neoplasia.

5. Squamous cell carcinomas in Fanconi's anemia.

Review 6. Genetic factors in the etiology of cancer.

7. Spontaneous chromosomal breakage and high incidence of leukemia in inherited disease.

8. The influence of chemotherapy on survival in acute leukemia. 3. A comparison of patients treated during 1958-1964 with those treated in two sequentially preceding periods.

Review 1. Genetics of neoplasia--impact of ecogenetics on oncogenesis. A review.

2. Body proportions in Fanconi anemia heterozygotes.

3. Functional defects in the fanconi anemia pathway in pancreatic cancer cells.

4. Spectrum of anomalies in Fanconi anaemia.