| Literature DB >> 10654414 |
J Ma1, S R Starck, S M Hecht.
Abstract
Bioassay-guided fractionation of an active methyl ethyl ketone extract of Tetracera boiviniana, using a sensitive assay to monitor DNA polymerase beta inhibition, resulted in the isolation of three known triterpenoids, betulinic acid (1), 3-cis-p-coumaroyl maslinic acid (2), and 3-trans-p-coumaroyl maslinic acid (3). Compounds 1-3 inhibited DNA polymerase beta with IC50 values of 14, 15, and 4.2 microM in the presence of bovine serum albumin (BSA) and 6.5, 7.5, and 2.0 microM in the absence of BSA, respectively. Further, compounds 1-3 potentiated the effects of bleomycin in cultured P-388D1 cells.Entities:
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Year: 1999 PMID： 10654414 DOI： 10.1021/np990326p
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050