| Literature DB >> 1065255 |
H M Golomb, J Rowley, J Vardiman, J Baron, G Locker, S Krasnow.
Abstract
Two patients with acute promyelocytic leukemia had an identical chromosomal abnormality detected by fluoresecence banding. In each case, the clinical course was rapidly fatal, and was characterized by a lack of response to chemotherapy with cytarabine and thioguanine, and was complicated by disseminated intravascular coagulation. Bone marrow cells from each patient contained 46 chromosomes; in each instance, however, one chromosome 17 had a deletion of almost one half of the proximal portion of the long arm [del(17)(q11q21 or 22)].Entities:
Mesh：
Year: 1976 PMID： 1065255
Source DB: PubMed Journal: Arch Intern Med ISSN： 0003-9926