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Literature DB >> 10652533

Insights into the functions of BRCA1 and BRCA2.

Abstract

Since BRCA1 and BRCA2 were cloned five years ago, unraveling their normal functions has posed fascinating problems for cancer biologists. Both genes are novel, and little of their normal function was revealed by their sequence. Both genes contribute to homologous recombination and DNA repair, to embryonic proliferation, to transcriptional regulation and, for BRCA1, to ubiquitination. But questions regarding BRCA1 and BRCA2 biology remain, and their resolution is critical for clinical development. Why do ubiquitously expressed genes that participate in universal pathways lead, when mutant, specifically to breast and ovarian cancer? Why are the same genes required for embryonic proliferation and for tumor suppression?

Entities: Disease Gene

Mesh：

Substances：

Year: 2000 PMID： 10652533 DOI： 10.1016/s0168-9525(99)01930-7

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

70 in total

1. BRCA1 can stimulate gene transcription by a unique mechanism.

Authors: G Nadeau; N Boufaied; A Moisan; K M Lemieux; C Cayanan; A N Monteiro; L Gaudreau
Journal: EMBO Rep Date: 2000-09 Impact factor: 8.807

Review 2. Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.

Authors: E Sonoda; C Morrison; Y M Yamashita; M Takata; S Takeda
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2001-01-29 Impact factor: 6.237

3. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors.

Authors: Lan Ko; Guemalli R Cardona; Alexandra Henrion-Caude; William W Chin
Journal: Mol Cell Biol Date: 2002-01 Impact factor: 4.272

4. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

Authors: Maria Kraakman-van der Zwet; Wilhelmina J I Overkamp; Rebecca E E van Lange; Jeroen Essers; Annemarie van Duijn-Goedhart; Ingrid Wiggers; Srividya Swaminathan; Paul P W van Buul; Abdellatif Errami; Raoul T L Tan; Nicolaas G J Jaspers; Shyam K Sharan; Roland Kanaar; Malgorzata Z Zdzienicka
Journal: Mol Cell Biol Date: 2002-01 Impact factor: 4.272

Insights into the functions of BRCA1 and BRCA2.

1. BRCA1 can stimulate gene transcription by a unique mechanism.

Review 2. Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.

3. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors.

4. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

5. Tumorigenesis in mice carrying a truncating Brca1 mutation.

6. Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex.

7. RAD51 localization and activation following DNA damage.

Review 8. Fine tuning chemotherapy to match BRCA1 status.

9. The dependence of the risk of breast cancer in women on their genotype.

10. BRCA1 variants in a family study of African-American and Latina women.