| Literature DB >> 10652479 |
M T Shata1, L Stevceva, S Agwale, G K Lewis, D M Hone.
Abstract
Bacille Calmette-Guerin (BCG), Listeria monocytogenes, Salmonellae and Shigellae have shown promise as vaccine vectors in experimental animal models. Although disappointing results in humans and non-human primates stalled the development of this vaccination strategy, interest in this approach was reinvigorated recently by the development of bacterial DNA-vaccine-vectors. The purpose of this review is to highlight the strengths and weaknesses of bacterial vaccine vectors, and to discuss the future prospects of these vaccine delivery systems.Entities:
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Year: 2000 PMID: 10652479 DOI: 10.1016/s1357-4310(99)01633-0
Source DB: PubMed Journal: Mol Med Today ISSN: 1357-4310