Literature DB >> 10652226

Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.

G Abbenante1, D M Kovacs, D L Leung, D J Craik, R E Tanzi, D P Fairlie.   

Abstract

A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC(50) = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation. Copyright 2000 Academic Press.

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Year:  2000        PMID： 10652226     DOI： 10.1006/bbrc.2000.2098

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

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Authors:  Jogender Mehla; Balwantsinh C Chauhan; Neelima B Chauhan
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2.  Activation of amyloid precursor protein processing by growth factors is dependent on Ras GTPase activity.

Authors:  Loredana Amigoni; Michela Ceriani; Fiorella Belotti; Giuseppina Minopoli; Enzo Martegani
Journal:  Neurochem Res       Date:  2010-12-15       Impact factor: 3.996

3.  Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death.

Authors:  Cristina d'Abramo; Sara Massone; Jean-Marc Zingg; Antonio Pizzuti; Philippe Marambaud; Bruno Dalla Piccola; Angelo Azzi; Umberto M Marinari; Maria A Pronzato; Roberta Ricciarelli
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Review 4.  Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.

Authors:  Kumar Sambamurti; Nigel H Greig; Debomoy K Lahiri
Journal:  Neuromolecular Med       Date:  2002       Impact factor: 3.843

5.  Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40.

Authors:  Cindy M Sondag; Colin K Combs
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Review 6.  BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis.

Authors:  Neville Marks; Martin J Berg
Journal:  Neurochem Res       Date:  2009-09-17       Impact factor: 3.996

7.  Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells.

Authors:  Henri J Huttunen; Luigi Puglielli; Blake C Ellis; Laura A MacKenzie Ingano; Dora M Kovacs
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Authors:  Shuhei Ishikura; Yuri Iwaihara; Yoko Tanaka; Hao Luo; Kensuke Nishi; Keiko Doi; Midori Koyanagi; Tadashi Okamura; Toshiyuki Tsunoda; Senji Shirasawa
Journal:  J Biol Chem       Date:  2016-05-20       Impact factor: 5.157

9.  Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.

Authors:  Claudia Litterst; Anastasios Georgakopoulos; Junichi Shioi; Enrico Ghersi; Thomas Wisniewski; Rong Wang; Andreas Ludwig; Nikolaos K Robakis
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10.  An AICD-based functional screen to identify APP metabolism regulators.

Authors:  Can Zhang; Preeti J Khandelwal; Ranjita Chakraborty; Trinna L Cuellar; Srikant Sarangi; Shyam A Patel; Christopher P Cosentino; Michael O'Connor; Jeremy C Lee; Rudolph E Tanzi; Aleister J Saunders
Journal:  Mol Neurodegener       Date:  2007-08-24       Impact factor: 14.195
  10 in total

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