BACKGROUND: Hypopharyngeal cancer is closely associated with smoking, drinking, and malnutrition. Recent findings reveal that carcinogenesis depends on genetic aberrations. MATERIALS AND METHODS: Eighty-one patients with hypopharyngeal cancer were analyzed for p53, CCND1, and p27, and 72 patients were analyzed for p21, immunohistochemically. RESULTS: p53 overexpression was found in 70%, CCND1 in 17%, p21 in 29%, and p27 in 32%. The low intensity of p27 expression correlated with poor prognosis, but the level of expression of p53, CCND1, and p21 did not. CONCLUSION: The immunohistochemical analysis of p27 provides a possible tool in determining the prognosis of patients with hypopharyngeal cancer.
BACKGROUND:Hypopharyngeal cancer is closely associated with smoking, drinking, and malnutrition. Recent findings reveal that carcinogenesis depends on genetic aberrations. MATERIALS AND METHODS: Eighty-one patients with hypopharyngeal cancer were analyzed for p53, CCND1, and p27, and 72 patients were analyzed for p21, immunohistochemically. RESULTS:p53 overexpression was found in 70%, CCND1 in 17%, p21 in 29%, and p27 in 32%. The low intensity of p27 expression correlated with poor prognosis, but the level of expression of p53, CCND1, and p21 did not. CONCLUSION: The immunohistochemical analysis of p27 provides a possible tool in determining the prognosis of patients with hypopharyngeal cancer.
Authors: Mark J Jameson; Linnea E Taniguchi; Kyle K VanKoevering; Menachem M Stuart; Christian R Francom; Rolando E Mendez; Andrew D Beckler; Hans T Carlson; Christopher Y Thomas; Ashraf A Khalil Journal: J Oral Pathol Med Date: 2012-10-26 Impact factor: 4.253