Literature DB >> 10650323

Increased glycolytic substrate protection improves ischemic cardiac dysfunction and reduces injury.

C S Apstein1.   

Abstract

Early clinical trials of glucose-insulin-potassium for acute myocardial infarction were inconclusive. However, several recent placebo-controlled, prospective, randomized clinical trials of glucose-insulin-potassium for acute myocardial infarction or metabolic support during and after cardiac surgery have demonstrated its efficacy. These clinical results are supported by experimental studies that have shown a strong protective effect of increased glycolytic substrate on ischemic myocardium in concert with an improved bioenergetic status.

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Year:  2000        PMID： 10650323     DOI： 10.1067/mhj.2000.103920

Source DB:  PubMed          Journal:  Am Heart J        ISSN： 0002-8703            Impact factor:   4.749


  9 in total

Review 1.  Potential beneficial mechanisms of insulin (glucose-potassium) in acute myocardial infarction.

Authors:  I C C van der Horst; F Zijlstra
Journal:  Neth Heart J       Date:  2005-06       Impact factor: 2.380

2.  Substrate dependence of the postischemic cardiomyocyte recovery: dissociation between functional, metabolic and injury markers.

Authors:  Cindy Tissier; David Vandroux; Lisa Devillard; Amandine Brochot; Daniel Moreau; Luc Rochette; Pierre Athias
Journal:  Mol Cell Biochem       Date:  2005-05       Impact factor: 3.396

3.  Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia.

Authors:  Kayla M Pound; Grace M Arteaga; Mathew Fasano; Tanganyika Wilder; Susan K Fischer; Chad M Warren; Adam R Wende; Mariam Farjah; E Dale Abel; R John Solaro; E Douglas Lewandowski
Journal:  J Mol Cell Cardiol       Date:  2011-05-26       Impact factor: 5.000

4.  Carnitine worsens both injury and recovery of contractile function after transient ischemia in perfused rat heart.

Authors:  R Díaz; J Lorita; M Soley; I Ramírez
Journal:  J Physiol Biochem       Date:  2008-03       Impact factor: 4.158

5.  Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction.

Authors:  Massimiliano Gnecchi; Huamei He; Luis G Melo; Nicolas Noiseaux; Fulvio Morello; Rudolf A de Boer; Lunan Zhang; Richard E Pratt; Victor J Dzau; Joanne S Ingwall
Journal:  Stem Cells       Date:  2009-04       Impact factor: 6.277

Review 6.  Cardioprotection in females: a role for nitric oxide and altered gene expression.

Authors:  Elizabeth Murphy; Charles Steenbergen
Journal:  Heart Fail Rev       Date:  2007-12       Impact factor: 4.214

7.  Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging.

Authors:  Bryan W Reutter; Ronald H Huesman; Kathleen M Brennan; Rostyslav Boutchko; Stephen M Hanrahan; Grant T Gullberg
Journal:  Int J Mol Imaging       Date:  2010-12-08

8.  One-Year Outcome of Intensive Insulin Therapy Combined to Glucose-Insulin-Potassium in Acute Coronary Syndrome: A Randomized Controlled Study.

Authors:  Wahid Bouida; Kaouthar Beltaief; Mohamed Amine Msolli; Nasri Bzeouich; Adel Sekma; Malek Echeikh; Malek Mzali; Hamdi Boubaker; Mohamed Habib Grissa; Riadh Boukef; Mohsen Hassine; Zohra Dridi; Asma Belguith; Fadhel Najjar; Ines Khochtali; Semir Nouira
Journal:  J Am Heart Assoc       Date:  2017-11-14       Impact factor: 5.501

9.  MicroRNA‑20b‑5p promotes ventricular remodeling by targeting the TGF‑β/Smad signaling pathway in a rat model of ischemia‑reperfusion injury.

Authors:  Zhao-Guang Liang; Hong Yao; Rong-Sheng Xie; Chun-Lin Gong; Ye Tian
Journal:  Int J Mol Med       Date:  2018-05-18       Impact factor: 4.101
  9 in total

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