| Literature DB >> 10650101 |
F D Horgen1, D B delos Santos, G Goetz, B Sakamoto, Y Kan, H Nagai, P J Scheuer.
Abstract
A new cyclic depsipeptide, kahalalide O (1), was isolated from the sacoglossan Elysia ornata and its algal diet Bryopsis sp. The structure was elucidated primarily by NMR and MS spectral methods, and the stereochemistry of the amino acid residues was determined by chiral HPLC and Marfey analyses. Unlike the related metabolite kahalalide F, which is in development as a potential anticancer agent, kahalalide O (1) was inactive in arresting the growth of P-388, A549, HT29, and MEL28 cancer cell lines in vitro.Entities:
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Year: 2000 PMID： 10650101 DOI： 10.1021/np990402o
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050