| Literature DB >> 10650087 |
R Tanaka1, K Kasubuchi, S Kita, H Tokuda, H Nishino, S Matsunaga.
Abstract
Three new ergostane-type steroids, 3beta-hydroxy-4alpha, 14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-11 -one (1); 3beta, 11alpha-dihydroxy-4alpha,14alpha-dimethyl-5alpha -ergosta-8, 24(28)-dien-7-one (2); and 3beta,7alpha-dihydroxy-4alpha, 14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-11 -one (3), were isolated, together with two known triterpenoids, wrightial and lup-20(30)-ene-3beta,29-diol from the whole herb of Euphorbia chamaesyce. Compound 3 showed a potent inhibitory effect on Epstein-Barr virus early antigen activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).Entities:
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Year: 2000 PMID： 10650087 DOI： 10.1021/np990394b
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050