Literature DB >> 10649968

Structural determinants of efficacy for kappa opioid receptors in the orvinol series: 7,7-spiro analogues of buprenorphine.

S M Husbands1, J W Lewis.   

Abstract

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Year:  2000        PMID： 10649968     DOI： 10.1021/jm991165p

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  6 in total

1.  Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.

Authors:  Nick P R Nieland; Humphrey A Moynihan; Simon Carrington; Jillian Broadbear; James H Woods; John R Traynor; Stephen M Husbands; John W Lewis
Journal:  J Med Chem       Date:  2006-08-24       Impact factor: 7.446

2.  Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.

Authors:  Gerta Cami-Kobeci; Willma E Polgar; Taline V Khroyan; Lawrence Toll; Stephen M Husbands
Journal:  J Med Chem       Date:  2011-09-07       Impact factor: 7.446

3.  Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.

Authors:  David Rennison; Adrian P Neal; Gerta Cami-Kobeci; Mario D Aceto; Fernando Martinez-Bermejo; John W Lewis; Stephen M Husbands
Journal:  J Med Chem       Date:  2007-09-22       Impact factor: 7.446

4.  Orvinols with mixed kappa/mu opioid receptor agonist activity.

Authors:  Benjamin M Greedy; Faye Bradbury; Mark P Thomas; Konstantinos Grivas; Gerta Cami-Kobeci; Ashley Archambeau; Kelly Bosse; Mary J Clark; Mario Aceto; John W Lewis; John R Traynor; Stephen M Husbands
Journal:  J Med Chem       Date:  2013-04-03       Impact factor: 7.446

5.  C7β-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors.

Authors:  Juan Pablo Cueva; Christopher Roche; Mehrnoosh Ostovar; Vinod Kumar; Mary J Clark; Todd M Hillhouse; John W Lewis; John R Traynor; Stephen M Husbands
Journal:  J Med Chem       Date:  2015-05-06       Impact factor: 7.446

6.  Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.

Authors:  Vinod Kumar; Irna E Ridzwan; Konstantinos Grivas; John W Lewis; Mary J Clark; Claire Meurice; Corina Jimenez-Gomez; Irina Pogozheva; Henry Mosberg; John R Traynor; Stephen M Husbands
Journal:  J Med Chem       Date:  2014-05-09       Impact factor: 7.446
  6 in total

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