Literature DB >> 10649413

Efficient Hydrolysis of RNA by a PNA - Diethylenetriamine Adduct.

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Abstract

The introduction of a urea bond linking a protected diethylenetriamine (DETA) unit and the terminal amino group of a resin-bound peptide nucleic acid (PNA) decamer gave access to a PNA - DETA adduct (shown here), which hydrolyzed the target 25-mer RNA rapidly and sequence specifically.

Entities:  

Year:  2000        PMID： 10649413     DOI： 10.1002/(sici)1521-3773(20000117)39:2<369::aid-anie369>3.0.co;2-a

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  5 in total

1.  Hydrolysis of bulged nucleotides in hybrids formed by RNA and imidazole-derivatized oligo-2'-O-methylribonucleotides.

Authors:  Anthony D Saleh; Paul S Miller
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2011-03       Impact factor: 1.381

2.  A peptide template as an allosteric supramolecular catalyst for the cleavage of phosphate esters.

Authors:  Alessandro Scarso; Ute Scheffer; Michael Göbel; Quirinus B Broxterman; Bernard Kaptein; Fernando Formaggio; Claudio Toniolo; Paolo Scrimin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-09       Impact factor: 11.205

3.  Highly efficient catalytic RNA cleavage by the cooperative action of two Cu(II) complexes embodied within an antisense oligonucleotide.

Authors:  Satoshi Sakamoto; Takashi Tamura; Takako Furukawa; Yasuo Komatsu; Eiko Ohtsuka; Masaya Kitamura; Hideo Inoue
Journal:  Nucleic Acids Res       Date:  2003-03-01       Impact factor: 16.971

4.  Cleavage of pyrene-stabilized RNA bulge loops by trans-(±)-cyclohexane-1,2-diamine.

Authors:  Sejal Patel; Jagruti Rana; Jyoti Roy; Haidong Huang
Journal:  Chem Cent J       Date:  2012-01-13       Impact factor: 4.215

5.  Hitting bacteria at the heart of the central dogma: sequence-specific inhibition.

Authors:  Louise Carøe Vohlander Rasmussen; Hans Uffe Sperling-Petersen; Kim Kusk Mortensen
Journal:  Microb Cell Fact       Date:  2007-08-10       Impact factor: 5.328
  5 in total

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