Literature DB >> 10649341

2-Phenylquinoline-Carbohydrate Hybrids: Molecular Design, Chemical Synthesis, and Evaluation of a New Family of Light-Activatable DNA-Cleaving Agents.

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Abstract

Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity

Entities:  

Year:  1999        PMID： 10649341

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  3 in total

1.  Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics.

Authors:  Wei Shi; Robert S Coleman; Todd L Lowary
Journal:  Org Biomol Chem       Date:  2009-07-17       Impact factor: 3.876

2.  N-Isopropyl-6-methyl-2-phenyl-quinoline-3-carboxamide.

Authors:  Saida Benzerka; Abdelmalek Bouraiou; Sofiane Bouacida; Thierry Roisnel; Ali Belfaitah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-08-18

Review 3.  Chemical Methods to Knock Down the Amyloid Proteins.

Authors:  Na Gao; Yong-Xiang Chen; Yu-Fen Zhao; Yan-Mei Li
Journal:  Molecules       Date:  2017-06-01       Impact factor: 4.411
  3 in total

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