[Paraneoplastic vanishing bile duct syndrome in a case of Hodgkin's disease].

We report the case of a man whose Hodgkin's disease was diagnosed at the same time as ductopenia. Cholestasis partially regressed after lymphoma was treated. When Hodgkin's disease relapsed two years later, cholestasis reappeared and liver biopsy again showed ductopenia. Treatment of relapse resulted in remission and cholestasis resolved. Liver biopsies never showed infiltration by lymphoma during the course of the disease. The usual causes of ductopenia were ruled out. This case report emphasizes that paraneoplastic ductopenia may complicate Hodgkin's disease. Such ductopenia may evolve towards biliary cirrhosis and require liver transplantation.