Literature DB >> 10648806

Inositol 1,4,5-trisphosphate receptor associated with focal contact cytoskeletal proteins.

T Sugiyama1, Y Matsuda, K Mikoshiba.   

Abstract

The linkage between inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) and cytoskeletal proteins is considered to be important in cell function. In the present study, the association of IP(3)R subtypes with cytoskeletal proteins was examined using monoclonal antibodies specific to each IP(3)R subtype. We found that IP(3)R type 2 colocalized with talin, a focal contact cytoskeletal protein. IP(3)R type 2 exhibited a patchy distribution in the peripheral cytoplasm differently from type 1 and type 3 IP(3)R. Furthermore, IP(3)R subtypes co-immunoprecipitated with talin, vinculin and alpha-actin, but not alpha-actinin or paxillin.

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Year:  2000        PMID： 10648806     DOI： 10.1016/s0014-5793(99)01732-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Subcellular distribution of Homer 1b/c in relation to endoplasmic reticulum and plasma membrane proteins in Purkinje neurons.

Authors:  Dorianna Sandonà; Alessandra Scolari; Katsuiko Mikoshiba; Pompeo Volpe
Journal:  Neurochem Res       Date:  2003-08       Impact factor: 3.996

Review 2.  Inositol trisphosphate receptors in smooth muscle cells.

Authors:  Damodaran Narayanan; Adebowale Adebiyi; Jonathan H Jaggar
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-03-23       Impact factor: 4.733

3.  Basal Vascular Smooth Muscle Cell Tone in eNOS Knockout Mice Can Be Reversed by Cyclic Stretch and Is Independent of Age.

Authors:  Sofie De Moudt; Jhana O Hendrickx; Guido R Y De Meyer; Wim Martinet; Paul Fransen
Journal:  Front Physiol       Date:  2022-04-28       Impact factor: 4.755

4.  Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.

Authors:  Qin Wang; Dhaarmini Rajshankar; Donald R Branch; Katherine A Siminovitch; Maria Teresa Herrera Abreu; Gregory P Downey; Christopher A McCulloch
Journal:  J Biol Chem       Date:  2009-06-03       Impact factor: 5.157

5.  Distribution of inositol 1,4,5-trisphosphate receptors in rat osteoclasts.

Authors:  Kazumasa Morikawa; Tetsuya Goto; Akihiko Tanimura; Shigeru Kobayashi; Kenshi Maki
Journal:  Acta Histochem Cytochem       Date:  2008-04-26       Impact factor: 1.938

Review 6.  Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs.

Authors:  David L Prole; Colin W Taylor
Journal:  J Physiol       Date:  2016-02-24       Impact factor: 5.182
  6 in total

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