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Literature DB >> 10647173

Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition.

Abstract

Water molecules are found in abundance in protein-protein and protein-DNA interfaces. Although interface solvent molecules exchange quickly with the bulk solvent, structural and biochemical data suggest that water-mediated interactions are as important as direct hydrogen bonds in the stability and specificity of recognition.

Entities: Chemical

Mesh：

Substances：
Proteins
Water
DNA

Year: 1999 PMID： 10647173 DOI： 10.1016/s0969-2126(00)88333-1

Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006

Keyword Cloud
Cited

57 in total

1. Crystal structure of the holliday junction DNA in complex with a single RuvA tetramer.

Authors: M Ariyoshi; T Nishino; H Iwasaki; H Shinagawa; K Morikawa
Journal: Proc Natl Acad Sci U S A Date: 2000-07-18 Impact factor: 11.205

2. Standard atomic volumes in double-stranded DNA and packing in protein--DNA interfaces.

Authors: K Nadassy; I Tomás-Oliveira; I Alberts; J Janin; S J Wodak
Journal: Nucleic Acids Res Date: 2001-08-15 Impact factor: 16.971

3. Structural analysis of conserved base pairs in protein-DNA complexes.

Authors: Leonid A Mirny; Mikhail S Gelfand
Journal: Nucleic Acids Res Date: 2002-04-01 Impact factor: 16.971

4. Thermodynamic analysis of the binding of component enzymes in the assembly of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus.

Authors: Hyo-Il Jung; Simon J Bowden; Alan Cooper; Richard N Perham
Journal: Protein Sci Date: 2002-05 Impact factor: 6.725

5. A simple physical model for binding energy hot spots in protein-protein complexes.

Authors: Tanja Kortemme; David Baker
Journal: Proc Natl Acad Sci U S A Date: 2002-10-15 Impact factor: 11.205

6. Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry.

Authors: Ewald T J van den Bremer; Wim Jiskoot; Richard James; Geoffrey R Moore; Colin Kleanthous; Albert J R Heck; Claudia S Maier
Journal: Protein Sci Date: 2002-07 Impact factor: 6.725

Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition.

1. Crystal structure of the holliday junction DNA in complex with a single RuvA tetramer.

2. Standard atomic volumes in double-stranded DNA and packing in protein--DNA interfaces.

3. Structural analysis of conserved base pairs in protein-DNA complexes.

4. Thermodynamic analysis of the binding of component enzymes in the assembly of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus.

5. A simple physical model for binding energy hot spots in protein-protein complexes.

6. Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry.

7. Epitope mapping for the monoclonal antibody that inhibits intramolecular electron transfer in flavocytochrome b2.

8. Water and proteins: a love-hate relationship.

9. The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction.

10. Determination of the interfacial water content in protein-protein complexes from free energy simulations.