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Literature DB >> 10644720

Role of lumican in the corneal epithelium during wound healing.

S Saika¹, A Shiraishi, C Y Liu, J L Funderburgh, C W Kao, R L Converse, W W Kao.

Abstract

Lumican regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as a glycoprotein. In normal unwounded cornea, lumican is expressed by stromal keratocytes. Our data show that injured mouse corneal epithelium ectopically and transiently expresses lumican during the early phase of wound healing, suggesting a potential lumican functionality unrelated to regulation of collagen fibrillogenesis, e. g. modulation of epithelial cell adhesion or migration. An anti-lumican antibody was found to retard corneal epithelial wound healing in cultured mouse eyes. Healing of a corneal epithelial injury in Lum(-/-) mice was significantly delayed compared with Lum(+/-) mice. These observations indicate that lumican expressed in injured epithelium may modulate cell behavior such as adhesion or migration, thus contributing to corneal epithelial wound healing.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2000 PMID： 10644720 PMCID： PMC3580337 DOI： 10.1074/jbc.275.4.2607

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

45 in total

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Journal: J Biol Chem Date: 1997-10-31 Impact factor: 5.157

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Journal: Invest Ophthalmol Vis Sci Date: 1997-05 Impact factor: 4.799

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Journal: J Biol Chem Date: 1999-04-02 Impact factor: 5.157

4. Characterization and expression of the mouse lumican gene.

Authors: S Ying; A Shiraishi; C W Kao; R L Converse; J L Funderburgh; J Swiergiel; M R Roth; G W Conrad; W W Kao
Journal: J Biol Chem Date: 1997-11-28 Impact factor: 5.157

5. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.

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Journal: Invest Ophthalmol Vis Sci Date: 1998-03 Impact factor: 4.799

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75 in total

1. Downregulation of lumican enhanced mitotic defects and aneuploidy in lung cancer cells.

Authors: Cheng-Ta Yang; Ping-Chih Hsu; Shu-Er Chow
Journal: Cell Cycle Date: 2019-11-24 Impact factor: 4.534

2. Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-alpha signaling.

Authors: Yasuhito Hayashi; Chia-Yang Liu; James J Jester; Miyuki Hayashi; I-Jong Wang; James L Funderburgh; Shizuya Saika; Peter J Roughley; Candace Whei-Cheng Kao; Winston Whei-Yang Kao
Journal: Dev Biol Date: 2005-01-01 Impact factor: 3.582

3. Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing.

Authors: Shizuya Saika; Kazuo Ikeda; Osamu Yamanaka; Kathleen C Flanders; Yuka Okada; Takeshi Miyamoto; Ai Kitano; Akira Ooshima; Yuji Nakajima; Yoshitaka Ohnishi; Winston W-Y Kao
Journal: Am J Pathol Date: 2006-06 Impact factor: 4.307

4. Non-enzymatic glycation of type I collagen diminishes collagen-proteoglycan binding and weakens cell adhesion.

Authors: Kristin L Reigle; Gloria Di Lullo; Kevin R Turner; Jerold A Last; Inna Chervoneva; David E Birk; James L Funderburgh; Elizabeth Elrod; Markus W Germann; Charles Surber; Ralph D Sanderson; James D San Antonio
Journal: J Cell Biochem Date: 2008-08-01 Impact factor: 4.429

5. Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan.

Authors: Guiyun Zhang; Shoujun Chen; Silvia Goldoni; Bennett W Calder; Holly C Simpson; Rick T Owens; David J McQuillan; Marian F Young; Renato V Iozzo; David E Birk
Journal: J Biol Chem Date: 2009-01-09 Impact factor: 5.157

Review 6. Cell Therapy of Corneal Diseases.

Authors: Winston W-Y Kao; Vivien J Coulson-Thomas
Journal: Cornea Date: 2016-11 Impact factor: 2.651

10. Lumican regulates ventilation-induced epithelial-mesenchymal transition through extracelluar signal-regulated kinase pathway.

Authors: Li-Fu Li; Pao-Hsien Chu; Cheng-Yiu Hung; Winston W-Y Kao; Meng-Chih Lin; Yung-Yang Liu; Cheng-Ta Yang
Journal: Chest Date: 2013-05 Impact factor: 9.410