Literature DB >> 10643899

Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population.

J Hu1, F Miyatake, Y Aizu, H Nakagawa, S Nakamura, A Tamaoka, R Takahash, K Urakami, M Shoji.   

Abstract

We compared the distribution of an insertion (I)/deletion (D) polymorphism of the gene coding for the angiotensin-converting enzyme (ACE) in 133 Japanese sporadic Alzheimer disease (AD) patients with 257 controls. The association between AD and ACE genotypes or alleles was found to be significant. The frequency of II genotypes was 1.4 times higher in AD than controls, while that of DD genotypes was only 0.4 times as high. The altered distribution of ACE alleles in patients with AD appeared to be independent of apolipoprotein E.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10643899     DOI： 10.1016/s0304-3940(99)00827-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  15 in total

1.  No association of angiotensin I converting enzyme I/D polymorphism with domain-specific cognitive function in aged men without dementia.

Authors:  Mu-En Liu; Shih-Jen Tsai; Ti Lu; Cheng-Jee Hong; Ming-Chao Chen; Shoa-Lin Lin; Heng-Liang Yeh; Yan-Chiou Ku
Journal:  Neuromolecular Med       Date:  2011-08-11       Impact factor: 3.843

2.  Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase.

Authors:  Alda Pereira da Silva; Andreia Matos; Laura Aguiar; Nuno Ramos-Marques; Ricardo Ribeiro; Ângela Gil; João Gorjão-Clara; Manuel Bicho
Journal:  Mol Cell Biochem       Date:  2018-11-20       Impact factor: 3.396

3.  Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.

Authors:  Tricia A Thornton-Wells; Jason H Moore; Eden R Martin; Margaret A Pericak-Vance; Jonathan L Haines
Journal:  Genet Epidemiol       Date:  2008-04       Impact factor: 2.135

4.  An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

Authors:  Todd L Edwards; Margaret Pericak-Vance; Johnny R Gilbert; Jonathan L Haines; Eden R Martin; Marylyn D Ritchie
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-07-05       Impact factor: 3.568

Review 5.  The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses.

Authors:  Laura Morelli; Ramiro Llovera; Sandra Ibendahl; Eduardo M Castaño
Journal:  Neurochem Res       Date:  2002-11       Impact factor: 3.996

6.  Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.

Authors:  Kun Zou; Haruyasu Yamaguchi; Hiroyasu Akatsu; Takaaki Sakamoto; Mihee Ko; Kazushige Mizoguchi; Jian-Sheng Gong; Wenxin Yu; Takayuki Yamamoto; Kenji Kosaka; Katsuhiko Yanagisawa; Makoto Michikawa
Journal:  J Neurosci       Date:  2007-08-08       Impact factor: 6.167

7.  Influence of angiotensin I-converting enzyme gene polymorphism on hepatocellular carcinoma risk in China.

Authors:  Fang Yuan; Lu-Shun Zhang; Hong-Yu Li; Miao Liao; Meili Lv; Chongjie Zhang
Journal:  DNA Cell Biol       Date:  2013-04-09       Impact factor: 3.311

8.  Angiotensin-converting enzyme insertion/deletion polymorphism is not a major determining factor in the development of sporadic Alzheimer disease: evidence from an updated meta-analysis.

Authors:  Xue-bin Wang; Ning-hua Cui; Jie Yang; Xue-ping Qiu; Jia-jia Gao; Na Yang; Fang Zheng
Journal:  PLoS One       Date:  2014-10-31       Impact factor: 3.240

9.  Association between an angiotensin-converting enzyme gene polymorphism and Alzheimer's disease in a Tunisian population.

Authors:  Najiba Fekih-Mrissa; Ines Bedoui; Aycha Sayeh; Hajer Derbali; Meriem Mrad; Ridha Mrissa; Brahim Nsiri
Journal:  Ann Gen Psychiatry       Date:  2017-11-17       Impact factor: 3.455

10.  N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease.

Authors:  Elena V Kugaevskaya; Alexander V Veselovsky; Maria I Indeykina; Nina I Solovyeva; Maria S Zharkova; Igor A Popov; Eugene N Nikolaev; Alexey B Mantsyzov; Alexander A Makarov; Sergey A Kozin
Journal:  Sci Rep       Date:  2018-01-10       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.