| Literature DB >> 10643890 |
L Lilius1, S Froelich Fabre, H Basun, C Forsell, K Axelman, K Mattila, A Andreadis, M Viitanen, B Winblad, L Fratiglioni, L Lannfelt.
Abstract
In an effort to analyze the genetic role of tau in Alzheimer's disease (AD), 17 polymorphisms were identified. Eleven of these polymorphisms were in complete linkage disequilibrium and segregated as two haplotypes, A and B. The A and B haplotypes were investigated in 269 AD cases and 238 controls from two different sources, a clinic-based group (mean age of onset 65+/-9 years), and a population-based group (mean age of onset 80+/-5 years). A synergistic effect between the common tau genotype AA and apolipoprotein E (APOE epsilon4) was found in the clinic-based AD group. Our study suggests that the common tau genotype AA may interact with APOE epsilon4 in increasing the risk of AD in a subgroup of the AD population.Entities:
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Year: 1999 PMID： 10643890 DOI： 10.1016/s0304-3940(99)00833-2
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046