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Literature DB >> 106433

Prostaglandins in the brain of rats given, acutely, and chronically, a hyperthermic dose of met-enkephalin.

G M Scoto, C Spadaro, S Spampinato, R Arrigo-Reina, S Ferri.

Abstract

An enhanced prostaglandinlike activity is shown in homogenates of brain from rats treated intracerebroventricularly with 100 microgram of metenkephalin. The increase is significantly reduced by naloxone pretreatment. A relationship is proposed between generation of prostaglandins in the brain following met-enkephalin administration and hyperthermic effect of the opiatelike factor in the rat. Normalization of prostaglandinlike activity following chronic administration of met-enkephalin in the rat may also account for the development of tolerance to its thermic effect.

Entities: Chemical Species

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Year: 1979 PMID： 106433 DOI： 10.1007/bf00432297

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

14 in total

1. Effect of the opiate antagonist naloxone on body temperature in rats.

Authors: A Goldstein; P J Lowery
Journal: Life Sci Date: 1975-09-15 Impact factor: 5.037

2. Prostaglandin E2 and central cyclic nucleotides.

Authors: G C Folco; D Longiave; F Berti; R Fumagalli; R Paoletti
Journal: Adv Prostaglandin Thromboxane Res Date: 1976

3. Apomorphine and morphine stimulate prostaglandin biosynthesis.

Authors: H O Collier; W J McDonald-Gibson; S A Saeed
Journal: Nature Date: 1974-11-01 Impact factor: 49.962

4. Proceedings: Morphine and apomorphine stimulate prostaglandin production by rabbit brain homogenate.

Authors: H O Collier; W J McDonald-Gibson; S A Saeed
Journal: Br J Pharmacol Date: 1974-09 Impact factor: 8.739

5. Prostaglandins released by the spleen.

Authors: N Gilmore; J R Vane; J H Wyllie
Journal: Nature Date: 1968-06-22 Impact factor: 49.962

6. Temperature responses in the rat following intracerebral microinjection of morphine.

Authors: V J Lotti; P Lomax; R George
Journal: J Pharmacol Exp Ther Date: 1965-10 Impact factor: 4.030

7. Some thoughts on the significance of enkephalin, the endogenous ligand.

Authors: H W Kosterlitz; J Hughes
Journal: Life Sci Date: 1975-07-01 Impact factor: 5.037

8. Effects of Met-enkephalin on body temperature of normal and morphine-tolerant rats.

Authors: S Ferri; R Arrigo Reina; A Santagostino; G M Scoto; C Spadaro
Journal: Psychopharmacology (Berl) Date: 1978-07-19 Impact factor: 4.530

9. Morphine hyperthermia in the rat: an action on the central thermostats.

Authors: B Cox; M Ary; W Chesarek; P Lomax
Journal: Eur J Pharmacol Date: 1976-03 Impact factor: 4.432

10. Effect of muscarinic cholinergic drugs on morphine-induced catalepsy, antinociception and changes in brain dopamine metabolism.

Authors: S Kaakkola; L Ahtee
Journal: Psychopharmacology (Berl) Date: 1977-03-23 Impact factor: 4.530

4 in total