Literature DB >> 10642854

Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain.

E E Massarelli1, C A Casatti, A Kato, A C Camargo, J A Bauer, M J Glucksman, J L Roberts, S Hirose, E S Ferro.   

Abstract

Immunohistochemistry was used to analyze the rat brain distribution of thimet oligopeptidase and neurolysin. Both enzymes appear ubiquitously distributed within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed for thimet oligopeptidase. These data suggest that neurolysin and thimet oligopeptidase, endopeptidases sharing several functional and structural similarities, are present in distinctive intracellular compartments in neuronal cells.

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Year:  1999        PMID： 10642854     DOI： 10.1016/s0006-8993(99)02135-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  19 in total

1.  Nuclear Thimet oligopeptidase is coexpressed with oestrogen receptor alpha in hypothalamic cells and regulated by oestradiol in female mice.

Authors:  N E Cyr; L H Kua; L A Bruce; J G Chadwick; M J Tetel; A J Wolfson
Journal:  J Neuroendocrinol       Date:  2010-04-23       Impact factor: 3.627

2.  Intracellular peptides as natural regulators of cell signaling.

Authors:  Fernanda M Cunha; Denise A Berti; Zulma S Ferreira; Clécio F Klitzke; Regina P Markus; Emer S Ferro
Journal:  J Biol Chem       Date:  2008-07-10       Impact factor: 5.157

3.  Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site.

Authors:  Naomi J Wangler; Kira L Santos; Ines Schadock; Fred K Hagen; Emanuel Escher; Michael Bader; Robert C Speth; Vardan T Karamyan
Journal:  J Biol Chem       Date:  2011-10-28       Impact factor: 5.157

4.  Neurolysin knockout mice generation and initial phenotype characterization.

Authors:  Diogo M L P Cavalcanti; Leandro M Castro; José C Rosa Neto; Marilia Seelaender; Rodrigo X Neves; Vitor Oliveira; Fábio L Forti; Leo K Iwai; Fabio C Gozzo; Mihail Todiras; Ines Schadock; Carlos C Barros; Michael Bader; Emer S Ferro
Journal:  J Biol Chem       Date:  2014-04-09       Impact factor: 5.157

5.  Neuropeptidase activity is down-regulated by estradiol in steroid-sensitive regions of the hypothalamus in female mice.

Authors:  Lisa A Bruce; Nicole E Cyr; Jana W Qiao; Christa C Defries; Marc J Tetel; Adele J Wolfson
Journal:  Neuropeptides       Date:  2012-06-04       Impact factor: 3.286

6.  EP24.15 as a Potential Regulator of Kisspeptin Within the Neuroendocrine Hypothalamus.

Authors:  Nicole C Woitowich; Keith D Philibert; Randy J Leitermann; Manida Wungjiranirun; Janice H Urban; Marc J Glucksman
Journal:  Endocrinology       Date:  2015-12-11       Impact factor: 4.736

7.  Nuclear expression of renin-angiotensin system components in NRK-52E renal epithelial cells.

Authors:  Ebaa M Alzayadneh; Mark C Chappell
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2014-06-24       Impact factor: 1.636

8.  Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.

Authors:  J Y Huang; A M Bruno; C A Patel; A M Huynh; K D Philibert; M J Glucksman; R A Marr
Journal:  Neuroscience       Date:  2008-05-16       Impact factor: 3.590

9.  Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep.

Authors:  Allyson C Marshall; Nancy T Pirro; James C Rose; Debra I Diz; Mark C Chappell
Journal:  J Neurochem       Date:  2014-04-19       Impact factor: 5.372

10.  Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.

Authors:  Thaysa Paschoalin; Adriana K Carmona; Elaine G Rodrigues; Vitor Oliveira; Hugo P Monteiro; Maria A Juliano; Luiz Juliano; Luiz R Travassos
Journal:  Mol Cancer       Date:  2007-07-09       Impact factor: 27.401
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