Literature DB >> 10642554

A critical role for murine complement regulator crry in fetomaternal tolerance.

C Xu1, D Mao, V M Holers, B Palanca, A M Cheng, H Molina.   

Abstract

Complement is a component of natural immunity. Its regulation is needed to protect tissues from inflammation, but mice with a disrupted gene for the complement regulator decay accelerating factor were normal. Mice that were deficient in another murine complement regulator, Crry, were generated to investigate its role in vivo. Survival of Crry-/- embryos was compromised because of complement deposition and concomitant placenta inflammation. Complement activation at the fetomaternal interface caused the fetal loss because breeding to C3-/- mice rescued Crry-/- mice from lethality. Thus, the regulation of complement is critical in fetal control of maternal processes that mediate tissue damage.

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Year:  2000        PMID： 10642554     DOI： 10.1126/science.287.5452.498

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  156 in total

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Review 4.  Immunology of pregnancy. Implications for the mother.

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Review 5.  Antiphospholipid syndrome: multiple mechanisms.

Authors:  C G Mackworth-Young
Journal:  Clin Exp Immunol       Date:  2004-06       Impact factor: 4.330

Review 6.  A noninflammatory pathway for pregnancy loss: innate immune activation?

Authors:  Jane E Salmon
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8.  Amino acid patterns within short consensus repeats define conserved duplicons shared by genes of the RCA complex.

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Journal:  J Mol Evol       Date:  2004-08       Impact factor: 2.395

9.  Acute Trypanosoma cruzi infection in mouse induces infertility or placental parasite invasion and ischemic necrosis associated with massive fetal loss.

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10.  Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition.

Authors:  Saifur R Ahmad; Elaine A Lidington; Rieko Ohta; Noriko Okada; Michael G Robson; Kevin A Davies; Michael Leitges; Claire L Harris; Dorian O Haskard; Justin C Mason
Journal:  Immunology       Date:  2003-10       Impact factor: 7.397
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