Literature DB >> 10641133

CNS activity of Vitex negundo Linn. in mice.

M Gupta1, U K Mazumder, S R Bhawal.   

Abstract

Methanolic extract (ME) of the leaves of V. negundo potentiated significantly the sleeping time induced by pentobarbitone sodium, diazepam and chlorpromazine in mice. ME possesses analgesic properties and potentiated analgesia induced by morphine and pethidine. ME also showed significant protection against strychnine and leptazole induced convulsions. The results suggest that ME exhibits CNS depressant activity in a dose dependent manner.

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Year:  1999        PMID： 10641133

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN： 0019-5189            Impact factor:   0.818


  6 in total

1.  Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride.

Authors:  Sheikh A Tasduq; Peerzada J Kaiser; Bishan D Gupta; Vijay K Gupta; Rakesh K Johri
Journal:  World J Gastroenterol       Date:  2008-06-21       Impact factor: 5.742

2.  Vitex negundo protects against cerebral ischemia-reperfusion injury in mouse via attenuating behavioral deficits and oxidative damage.

Authors:  Kamakshi Mehta; Deepak Prabhakar Bhagwat; Palika Sehgal; Garima Mittal; Kapil Suchal
Journal:  Psychopharmacology (Berl)       Date:  2022-01-24       Impact factor: 4.530

3.  Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A(2) through molecular docking.

Authors:  Thangaraj Vinuchakkaravarthy; Kaliya Perumal Kumaravel; Samuthirapandian Ravichandran; Devadasan Velmurugan
Journal:  Bioinformation       Date:  2011-10-14

4.  Antiepileptic potential of Bacopa monnieri in the rat brain during PTZ-induced epilepsy with reference to cholinergic system and ATPases.

Authors:  E Komali; Ch Venkataramaiah; W Rajendra
Journal:  J Tradit Complement Med       Date:  2020-03-04

5.  Essential Oil Composition and Antibacterial Studies of Vitex negundo Linn. Extracts.

Authors:  S L Khokra; O Prakash; S Jain; K R Aneja; Yogita Dhingra
Journal:  Indian J Pharm Sci       Date:  2008 Jul-Aug       Impact factor: 0.975

6.  A clinical study to evaluate efficacy and safety of AHPL/AYTAB/0313 tablet in subjects suffering from osteoarthritis of knee(s).

Authors:  Sanjay U Nipanikar; Shailesh Deshpande; Ashutosh H Bhosale; Mayura V Jadhav-Shinde
Journal:  J Family Med Prim Care       Date:  2020-01-28
  6 in total

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